4-Chloro-1-(difluoromethoxy)-2-methylbenzene CAS 639826-17-8
| CAS No. | 639826-17-8 |
| Molecular Formula | C8H7ClF2O |
| Molecular Weight | 192.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-1-(difluoromethoxy)-2-methylbenzene (CAS 639826-17-8) is a high-purity analytical reference standard with the molecular formula C8H7ClF2O and a molecular weight of 192.59 g/mol.
4-Chloro-1-(difluoromethoxy)-2-methylbenzene (C8H7ClF2O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-1-(difluoromethoxy)-2-methylbenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7ClF2O |
| Molecular Weight | 192.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- (3-Chloro-2,6-difluorobenzyl)hydrazine (CAS 1000805-99-1)
- (R)-2-Chloro-2,2-difluoro-1-phenylethan-1-ol (CAS 119454-39-6)
- 1-chloro-2-(difluoromethoxy)-4-methylbenzene (CAS 1225665-64-4)
- (S)-2-Chloro-2,2-difluoro-1-phenylethan-1-ol (CAS 124095-23-4)
- 4-Chloro-2-(difluoromethoxy)-1-methylbenzene (CAS 1261449-29-9)
- 4-Chloro-1-(difluoromethyl)-2-methoxybenzene (CAS 1261449-35-7)
- 2-Chloro-1-(difluoromethoxy)-4-methyl-benzene (CAS 1261554-69-1)
- 1-Chloro-2-(difluoromethoxy)-3-methylbenzene (CAS 1261567-06-9)
Recommended Standards
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