2-(6-Chloro-8-methylimidazo[1,2-b]pyridazin-2-yl)acetic acid CAS 64068-12-8
| CAS No. | 64068-12-8 |
| Molecular Formula | C9H8ClN3O2 |
| Molecular Weight | 225.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(6-Chloro-8-methylimidazo[1,2-b]pyridazin-2-yl)acetic acid (C9H8ClN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies 2-(6-Chloro-8-methylimidazo[1,2-b]pyridazin-2-yl)acetic acid (CAS 64068-12-8), a certified reference material (molecular formula C9H8ClN3O2, MW 225.63 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8ClN3O2 |
| Molecular Weight | 225.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
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- Ethyl 5-chloro-3H-imidazo[4,5-b]pyridine-2-carboxylate (CAS 1044772-75-9)
- Ethyl 2-chloro-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate (CAS 1060816-62-7)
- ethyl 6-chloro-1H-pyrazolo[3,4-b]pyridine-3-carboxylate (CAS 1083181-27-4)
- 5-Chloro-1,3-dimethyl-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione (CAS 112734-83-5)
- Methyl 4-chloro-2-cyano-5-methoxybenzoate (CAS 1138220-78-6)
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Recommended Standards
- 2-(6-Chloro-7-methylimidazo[1,2-b]pyridazin-2-yl)acetic acid (CAS 64068-10-6)
- 2-Chloro-4-cyano-6-methoxyphenyl acetate (CAS 757220-09-0)
- 2-(4-Chlorophenyl)-5-imino-2,5-dihydrofuran-3,4-diol (CAS 7342-16-7)
- 2-Chloro-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-acetamide (CAS 612850-65-4)
- 4-Cyano-2-methoxybenzyl chloride (CAS 1260887-50-0)
- 2-(1-Aminocyclohexyl)-5-ethyl-6-methylpyrimidin-4(1h)-one hydrochloride (CAS 1333723-70-8)
- Boc-Ser(Ala-Fmoc)-OH (CAS 944283-07-2)
- 1,4,6-Trimethyl-1H-Indazole (CAS 1236127-58-4)
- 2-(Pyridin-3-yloxy)ethane-1-sulfonyl chloride (CAS 1344096-83-8)
- N-(4-(tert-Butyl)-2-cyclopropoxyphenyl)methanesulfonamide (CAS 1243285-83-7)
- (S)-N-(1-((3-Chloro-4-fluorophenyl)amino)-1-oxo-3-phenylpropan-2-yl)-3-oxo-3,4-dihydroquinoxaline-1(2H)-carboxamide (CAS 1014064-39-1)
- 1-(2-Fluoroethyl)-3-methyl-1H-pyrazole-4-sulfonyl chloride (CAS 1394021-33-0)
- 2-azabicyclo[3.2.2]nonane hydrochloride (CAS 5597-38-6)
- Pancreatic Polypeptide (bovine) (CAS 179986-89-1)
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