6-Chloro-8-methylimidazo[1,2-b]pyridazine-2-carboxylic acid CAS 64068-13-9
| CAS No. | 64068-13-9 |
| Molecular Formula | C8H6ClN3O2 |
| Molecular Weight | 211.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Chloro-8-methylimidazo[1,2-b]pyridazine-2-carboxylic acid.
6-Chloro-8-methylimidazo[1,2-b]pyridazine-2-carboxylic acid (CAS 64068-13-9), molecular formula C8H6ClN3O2 and molecular weight 211.61 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 6-Chloro-8-methylimidazo[1,2-b]pyridazine-2-carboxylic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 211.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Chloro-8-methylimidazo[1,2-b]pyridazine-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6ClN3O2 |
| Molecular Weight | 211.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 5-Chloro-6-methyl-3-nitro-1H-pyrrolo[2,3-b]pyridine (CAS 1000340-15-7)
- 3-Chloro-6-methyl-7-nitro-1H-indazole (CAS 1000342-46-0)
- 3-Chloro-6-methylpyrazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 1015846-76-0)
- Methyl 5-chloro-1H-imidazo[4,5-b]pyridine-2-carboxylate (CAS 1044772-73-7)
- Methyl 5-chloro-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate (CAS 1095822-65-3)
- 5-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid (CAS 1095822-69-7)
- 7-Chloro-5-methylimidazo[1,2-c]pyrimidine-2-carboxylic acid (CAS 117186-21-7)
- 6-Chloro-N'-hydroxy-1,3-benzoxazole-2-carboximidamide (CAS 1172606-71-1)
Recommended Standards
- 6-Chloro-1-methylpyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione (CAS 2618422-74-3)
- 6-Chloro-8-methylimidazo[1,2-b]pyridazine-3-carboxylic acid (CAS 2148895-39-8)
- 6-Chloro-1-methyl-7-nitro-1H-indazole (CAS 41926-09-4)
- 8-Chloro-2-methoxypyrido[2,3-b]pyrazin-3(4H)-one (CAS 2767412-89-3)
- 2H-Dithieno[3,2-e:2′,3′-g]benzotriazole10,13-dithia-3,4,5-triazatetracyclo[10.3.0.0²,⁶.0⁷,¹¹]pentadeca-1(12),2,5,7(11),8,14-hexaene (CAS 1415761-30-6)
- Sodium 2,4-Dinitrobenzenesulfonate (CAS 885-62-1)
- 3-Isopropyl-4-methyl-1H-indazole (CAS 1415741-72-8)
- 2-Amino-3-(ethylamino)propanoic acid (CAS 18507-25-0)
- 2-Hydrazinyl-2-oxo-N-((tetrahydrofuran-2-yl)methyl)acetamide (CAS 473828-11-4)
- tert-Butyl (1R,2R,5S)-2-(hydroxymethyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate (CAS 194737-55-8)
- (1-((2-Methylthiazol-4-yl)methyl)piperidin-3-yl)methanol (CAS 1249345-52-5)
- Z-b-sulfamoyl-L-Ala-OH (CAS 33662-45-2)
- 2-Fluoro-5-hydroxy-3-methoxypyridine (CAS 1227511-69-4)
- Insulin degludec (CAS 844439-96-9)
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