4-Bromopicolinoyl chloride CAS 64197-01-9
| CAS No. | 64197-01-9 |
| Molecular Formula | C6H3BrClNO |
| Molecular Weight | 220.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Bromopicolinoyl chloride.
4-Bromopicolinoyl chloride (CAS 64197-01-9), molecular formula C6H3BrClNO and molecular weight 220.45 g/mol, is a CATO reference standard with documented purity and traceability.
4-Bromopicolinoyl chloride (C6H3BrClNO) contains an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Bromopicolinoyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H3BrClNO |
| Molecular Weight | 220.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromopicolinoyl Standards
- (5-Bromopicolinoyl)-D-alanine (CAS 1344934-61-7)
- 1-(5-Bromopicolinoyl)pyrrolidine-3-carboxylic acid (CAS 1409029-98-6)
- n-(5-Bromopicolinoyl)-n-cyclopropylglycine (CAS 1482763-29-0)
- (S)-5-(4-(5-Bromopicolinoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl)-1-phenyl-3-(trifluoromethyl)pyridin-2(1H)-one (CAS 2132392-89-1)
Recommended Standards
- 3-Bromopyridine-4-carbonyl chloride (CAS 71541-33-8)
- 5-Bromo-3-chloropyridine-2-carbaldehyde (CAS 885168-04-7)
- 2-Bromopyridine-3-carbonyl chloride (CAS 654084-12-5)
- 5-Bromo-6-chloronicotinaldehyde (CAS 71702-00-6)
- 1-(2-Fluorobenzo[d]oxazol-4-yl)ethanone (CAS 1804471-44-0)
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- Ethyl 2-(3-aminopropyl)-4-methylthiazole-5-carboxylate (CAS 1017422-50-2)
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