Riboflavin Impurity 12 CAS 64480-68-8
| CAS No. | 64480-68-8 |
| Molecular Formula | C16H20N2O7 |
| Molecular Weight | 352.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Riboflavin Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Riboflavin Impurity 12 (CAS 64480-68-8, C16H20N2O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Riboflavin Impurity 12 (C16H20N2O7) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C16H20N2O7 |
| Molecular Weight | 352.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Nitrogen Atoms | 2 |
Related Riboflavin Standards
- Riboflavin Impurity 25 (CAS CATO-C4X-181925)
- Riboflavin Impurity 26 (CAS CATO-C4X-181926)
- Riboflavin Impurity 28 (CAS CATO-C4X-181928)
- Riboflavin Impurity N66 (CAS 21037-26-3)
- Riboflavin Impurity N17 (CAS 21037-25-2)
- Riboflavin Impurity 19 (CAS CATO-C4X-181919)
- Riboflavin lmpurity 20 (CAS 57609-95-7)
- Riboflavin Impurity 29 (CAS CATO-C4X-181929)
Recommended Standards
- Marbofloxacin EP Impurity C (CAS 100276-37-7)
- Sparfloxacin Impurity 1 (CAS CATO-C4X-21131)
- Voriconazole-d3 (CAS 137234-62-9 (unlabelled))
- Roxadustat (CAS 808118-40-3)
- Drotaverine Impurity 14 (CAS 5763-61-1)
- Dapoxetine Impurity 12 (CAS 3330-05-0)
- Pitavastatin Impurity 128 (CAS CATO-C4X-1037128)
- N-(6-Chloro-4-propoxypyrido[3,2-d]pyrimidin-2-yl)acetamide (CAS 897362-15-1)
- (Octahydro-9aH-quinolizin-9a-yl)methanamine (CAS 1809356-05-5)
- 5-chloro-6-ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazine-2-carboxamide (CAS 1254058-47-3)
- 1-[(2S)-pyrrolidin-2-yl]propan-1-one hydrochloride (CAS 1261486-13-8)
- 1-Methyl-1h-pyrazole-3,4-dicarbonyl dichloride (CAS 1171786-16-5)
- N-Pyridin-2-ylmethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (CAS 864754-23-4)
- Semaglutide impurity 237 (CAS CATO-C4X-2226237)
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