Riboflavin Impurity N66 CAS 21037-26-3
| CAS No. | 21037-26-3 |
| Molecular Formula | C19H25N3O4 |
| Molecular Weight | 359.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Riboflavin Impurity N66 (CAS 21037-26-3, C19H25N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Riboflavin Impurity N66 (C19H25N3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Riboflavin Impurity N66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H25N3O4 |
| Molecular Weight | 359.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 3 |
Related Riboflavin Standards
- Riboflavin Impurity N17 (CAS 21037-25-2)
- Riboflavin Impurity 25 (CAS CATO-C4X-181925)
- Riboflavin Impurity 26 (CAS CATO-C4X-181926)
- Riboflavin Impurity 28 (CAS CATO-C4X-181928)
- Riboflavin Impurity 12 (CAS 64480-68-8)
- Riboflavin Impurity 19 (CAS CATO-C4X-181919)
- Riboflavin lmpurity 20 (CAS 57609-95-7)
- Riboflavin Impurity N16 (CAS 5978-87-0)
Recommended Standards
- 3-(4-Methoxyphenyl)-6-(pyrrolidin-1-ylmethyl)-[1,2,4]triazolo[3,4-a]phthalazine (CAS 98124-14-2)
- 3-Benzhydryl-5-(4-methoxyphenoxy)-4,5-dihydroisoxazole (CAS 89249-65-0)
- 2-Naphthyl[6-(2-naphthyl)-3-pyridinyl]methanone (CAS 502841-00-1)
- 3-Benzyl 2-(tert-butyl) (1S,3S,4S)-5-oxo-2-azabicyclo[2.2.2]octane-2,3-dicarboxylate (CAS 2410984-37-9)
- Carfilzomib Impurity 11 (CAS 247068-82-2)
- Terbutaline impurity 101 (CAS 1226543-90-3)
- Ondansetron EP Impurity A (CAS 153139-56-1)
- 4-Bromo-1-cyclopropyl-1H-pyrazol-5-amine (CAS 1538500-53-6)
- 2-((3-(o-Tolyl)-1,2,4-oxadiazol-5-yl)methoxy)benzaldehyde (CAS 1120245-78-4)
- 5-Acetyl-2,3-Dihydro-1-Benzofuran (CAS 90843-31-5)
- 2-(Trifluoromethyl)piperidine hydrochloride (CAS 627533-08-8)
- Sugammadex Impurity Org244517-1 (CAS 3052554-61-4)
- 2-[(3-Fluorobenzyl)oxy]benzoyl chloride (CAS 1160250-82-7)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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