5-Chloro-3-fluorobenzene-1,2-diol CAS 645405-05-6
| CAS No. | 645405-05-6 |
| Molecular Formula | C6H4ClFO2 |
| Molecular Weight | 162.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 162.55 g/mol gives 5-Chloro-3-fluorobenzene-1,2-diol distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 5-Chloro-3-fluorobenzene-1,2-diol (CAS 645405-05-6), a certified reference material (molecular formula C6H4ClFO2, MW 162.55 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 5-Chloro-3-fluorobenzene-1,2-diol is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 162.55 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-Chloro-3-fluorobenzene-1,2-diol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4ClFO2 |
| Molecular Weight | 162.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 6-Chloro-5-fluoro-2-methylpyrimidin-4(3H)-one (CAS 105806-14-2)
- 4-Chloro-2-fluororesorcinol (CAS 1070868-27-7)
- 2-Chloro-5-fluoro-4-hydrazinylpyrimidine (CAS 1314936-62-3)
- 5-Chloro-6-fluoropyrimidine-2,4-diamine (CAS 1353054-66-6)
- (2-Chloro-5-fluoropyrimidin-4-yl)methanol (CAS 1463484-29-8)
- 4-Chloro-3-fluorobenzene-1,2-diol (CAS 162757-53-1)
- (6-Chloro-3-fluoropyrazin-2-yl)methanol (CAS 2639836-43-2)
- 4-Chloro-5-fluoro-6-methoxypyrimidine (CAS 2012583-91-2)
Recommended Standards
- 4-Chloro-6-(fluoromethyl)-1,3,5-triazin-2-amine (CAS 253870-34-7)
- Capecitabine Impurity 35 (CAS 1801-06-5)
- 2-Chloro-3,4-difluoro-1-methylbenzene (CAS 1026525-97-2)
- 3-Chloro-2,6-difluorotoluene (CAS 1208075-98-2)
- (4-methoxycarbonyl-2-thienyl)boronic acid (CAS 1333313-18-0)
- 4-Chloro-3-cyclopropylpyridine hydrochloride (CAS 1998216-32-2)
- 4-(Acridin-9-yl)-N,N-dimethylaniline (CAS 24275-68-1)
- [(Benzo[1,3]dioxole-5-carbonyl)-amino]-acetic acid ethyl ester (CAS 76208-96-3)
- Saxagliptin Impurity 4 (CAS 1564266-00-7)
- Dicloxacillin Impurity 3 (CAS CATO-C4X-16153)
- 1-ethynyl-2,3-difluoro-4-methoxybenzene (CAS 931108-29-1)
- 4-(3-Methylpyrazin-2-yl)butane-1,2,3-triol (CAS 163046-71-7)
- Methyl butylglycinate (CAS 204691-86-1)
- 263251-78-1 NMG938VJ6T D-3 Tavilermide [USAN:INN] UNII-NMG938VJ6T MIM-D3 MIM-D 3 D 3 (peptide) Tavilermide (CAS 263251-78-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com