Capecitabine Impurity 35 CAS 1801-06-5
| CAS No. | 1801-06-5 |
| Molecular Formula | C5H4ClFN2O |
| Molecular Weight | 162.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Capecitabine Impurity 35.
CATO supplies Capecitabine Impurity 35 (CAS 1801-06-5), a pharmacopoeial impurity reference standard (molecular formula C5H4ClFN2O, MW 162.55 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Capecitabine Impurity 35 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 162.55 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4ClFN2O |
| Molecular Weight | 162.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Capecitabine Standards
- Capecitabine Impurity 49 (CAS 638-41-5)
- Capecitabine Impurity 29 (CAS 5006-64-4)
- Capecitabine Impurity 36 (CAS 1993-63-1)
- Capecitabine Impurity 33 (CAS 78341-97-6)
- Capecitabine Impurity 50 (CAS 13039-75-3)
- Capecitabine Impurity 31 (CAS 72402-14-3)
- Capecitabine Impurity 46 (CAS 34980-66-0)
- Capecitabine Impurity 28 (CAS 862508-03-0)
Recommended Standards
- 5-Chloro-3-fluorobenzene-1,2-diol (CAS 645405-05-6)
- 2-Chloro-3,4-difluoro-1-methylbenzene (CAS 1026525-97-2)
- 4-Chloro-6-(fluoromethyl)-1,3,5-triazin-2-amine (CAS 253870-34-7)
- 3-Chloro-2,6-difluorotoluene (CAS 1208075-98-2)
- Cabozantinib Impurity 11 (CAS 748707-58-6)
- Loxoprofen Impurity 148 (CAS CATO-C4X-1488148)
- Lemborexant Impurity 29 (CAS CATO-C4X-304229)
- 4-(4,4-Dimethyl-1,3-oxazolidine-3-carbonyl)benzonitrile (CAS 866157-35-9)
- 18:1(2R-OH) Ceramide (CAS 1246298-52-1)
- 4-Benzyloxy-Alpha-cyanocinnamic acid (CAS 162882-36-2)
- 6-Fluoronaphthalene-1,3-diol (CAS 2450997-51-8)
- 6-Methoxy-2,3-dihydro-1h-indene-1-sulfonamide (CAS 1540156-98-6)
- 2-(5-((6-Bromo-3-nitroquinolin-4-yl)amino)pyridin-2-yl)-2-methylpropanenitrile (CAS 1370616-08-2)
- D-Tyr1-Tirzepatide (CAS CATO-CPTD788928)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com