3-{5-[3,5-di(trifluoromethyl)phenyl]-2-furyl}-1-phenylprop-2-en-1-one CAS 646497-84-9
| CAS No. | 646497-84-9 |
| Molecular Formula | C21H12F6O2 |
| Molecular Weight | 410.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-{5-[3,5-di(trifluoromethyl)phenyl]-2-furyl}-1-phenylprop-2-en-1-one is closely related to a steroid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-{5-[3,5-di(trifluoromethyl)phenyl]-2-furyl}-1-phenylprop-2-en-1-one (CAS 646497-84-9) is a high-purity analytical reference standard with the molecular formula C21H12F6O2 and a molecular weight of 410.31 g/mol.
The molecular framework of 3-{5-[3,5-di(trifluoromethyl)phenyl]-2-furyl}-1-phenylprop-2-en-1-one (C21H12F6O2) is characterized by a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H12F6O2 |
| Molecular Weight | 410.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
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Recommended Standards
- tert-Butyl 4-(((3-bromoimidazo[1,2-b]pyridazin-6-yl)amino)methyl)piperidine-1-carboxylate (CAS 1417297-96-1)
- 3-Bromo-9,9'-spirobi[fluoren]-2-amine (CAS 2131825-24-4)
- (1R,3S,4S)-tert-butyl 3-((2-amino-4-bromophenyl)carbamoyl)-2-azabicyclo[2.2.1]heptane-2-carboxylate (CAS 1256387-73-1)
- 4,4',4''-Phosphoryltribenzoic acid (CAS 807-19-2)
- Nitrazepam EP Impurity D (CAS 33311-76-1)
- 5-Bromo-N-(2-oxoazepan-3-yl)nicotinamide (CAS 1214126-67-6)
- 4-Amino-5-(2-fluorophenoxymethyl)-4h-1,2,4-triazole-3-thiol (CAS 733030-60-9)
- 4-(2-(Bromomethyl)-4-nitrophenyl)morpholine (CAS 1092352-78-7)
- 2,4-Dimethylbenzenesulfonohydrazide (CAS 18626-10-3)
- 3-(o-Tolyl)thiazolidine-2,4-dione (CAS 16240-02-1)
- 1-Methyl-5-(tributylstannyl)-1H-pyrazole (CAS 170682-50-5)
- 1,2,3,5-Tetramethyl-4-propylcyclopenta-1,3-diene (CAS 83321-20-4)
- Melphalan EP Impurity B DiHCl (CAS CATO-C4X-198820)
- Peptide YY (human) trifluoroacetate salt (CAS 118997-30-1)
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