4,5-Dichloro-1h-imidazole-2-carboxylic acid CAS 64736-53-4
| CAS No. | 64736-53-4 |
| Molecular Formula | C4H2Cl2N2O2 |
| Molecular Weight | 180.98 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4,5-Dichloro-1h-imidazole-2-carboxylic acid (C4H2Cl2N2O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4,5-Dichloro-1h-imidazole-2-carboxylic acid (CAS 64736-53-4) is a high-purity analytical reference standard with the molecular formula C4H2Cl2N2O2 and a molecular weight of 180.98 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4,5-Dichloro-1h-imidazole-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H2Cl2N2O2 |
| Molecular Weight | 180.98 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichloro Standards
- 3,4-Dichloro-1H-pyrazole-5-carboxylic acid (CAS 115964-19-7)
- 2,5-Dichloro-3-fluorophenol (CAS 1394927-62-8)
- 2,6-Dichloro-3-fluorophenol (CAS 1803854-58-1)
- 2,3-Dichloro-5-fluorophenol (CAS 1804515-85-2)
- 3,4-Dichloro-5-fluorophenol (CAS 1804515-92-1)
- 3,5-Dichloro-2-fluorophenol (CAS 1805479-52-0)
- 2,3-Dichloro-4-fluorophenol (CAS 934180-45-7)
- 2,3-Dichloro-6-fluorophenol (CAS 886497-60-5)
Recommended Standards
- 3-Iodopropanenitrile (CAS 2517-76-2)
- 4,5-Dichloropyridazine-3,6-diol (CAS 6641-32-3)
- 3-bromo-2-oxobutanoic acid (CAS 61964-74-7)
- 4-Bromo-3-oxobutanoic Acid (CAS 27807-85-8)
- 2-Bromo-5-methoxy-3-nitropyridine (CAS 1805025-96-0)
- Isovitexin (CAS 38953-85-4)
- 7-Bromo-3-chlorothieno[2,3-c]pyridine-2-carboxylic acid (CAS 1603136-58-8)
- 2-((4-(tert-Butyl)phenyl)amino)nicotinic acid (CAS 1041599-80-7)
- Mupirocin Impurity 28 (CAS CATO-C4X-170628)
- 2-[(cyclobutylmethyl)amino]-2-methylpropan-1-ol (CAS 1467508-64-0)
- (S)-2-Amino-N-cyclopropyl-N-(pyrazin-2-ylmethyl)propanamide (CAS 1354015-08-9)
- Tris(4-vinylphenyl)phosphane (CAS 95705-40-1)
- 5-Amino-1-(2-methylbutyl)pyridin-2(1h)-one (CAS 1251086-90-4)
- Semaglutide impurity 40 (CAS CATO-C4X-222640)
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