1-(Difluoromethyl)-2-nitrobenzene CAS 64747-65-5
| CAS No. | 64747-65-5 |
| Molecular Formula | C7H5F2NO2 |
| Molecular Weight | 173.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 1-(Difluoromethyl)-2-nitrobenzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 173.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies 1-(Difluoromethyl)-2-nitrobenzene (CAS 64747-65-5), a certified reference material (molecular formula C7H5F2NO2, MW 173.12 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5F2NO2 |
| Molecular Weight | 173.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 3-(Difluoromethyl)pyridine-4-carboxylic acid (CAS 1211541-32-0)
- 4-(Difluoromethyl)nicotinic acid (CAS 1211590-78-1)
- 3-(Difluoromethyl)pyridine-2-carboxylic acid (CAS 1256794-75-8)
- 4-(Difluoromethyl)picolinic acid (CAS 1256804-49-5)
- 2-(Difluoromethyl)pyridine-3-carboxylic acid (CAS 1256809-21-8)
- 5-(Difluoromethyl)nicotinic acid (CAS 1256817-25-0)
- 2-(Difluoromethyl)isonicotinic acid, 97% (CAS 1256818-14-0)
- 6-(Difluoromethyl)-2-pyridinecarboxylic Acid (CAS 1256824-41-5)
Recommended Standards
- (S)-5-Oxopyrrolidine-1,2-dicarboxylic acid (CAS 483369-82-0)
- 1-(Difluoromethyl)-2-oxo-1,2-dihydropyridine-4-carbaldehyde (CAS 2168703-41-9)
- (6-Fluoropyridin-3-yl)dimethylphosphine oxide (CAS 2503206-57-1)
- 1-(Difluoromethyl)-4-nitrobenzene (CAS 29848-57-5)
- Ethyl 5-(benzylamino)-3-phenyl-1,2,4-triazine-6-carboxylate (CAS 866051-63-0)
- 4-Amino-2-methyl-5-nitrobenzoic acid (CAS 408507-93-7)
- ((1H-benzo[d]imidazol-2-yl)methyl)glycine (CAS 99056-03-8)
- 3-Tert-butyl-1-ethyl-1h-pyrazole-4-carboxylic acid (CAS 1249030-93-0)
- 4,4,4-Trifluoro-n3,n3-dipropylbutane-1,3-diamine (CAS 1157129-73-1)
- 1-Bromo-4-chloroimidazo[1,2-a]quinoxaline (CAS 1254196-52-5)
- 5-Bromo-4-fluoro-2-methoxybenzaldehyde (CAS 923281-65-6)
- Methyl 3-[(4-methylphenyl)sulfanyl]-4-nitrobenzoate (CAS 1280787-23-6)
- Vapendavir (CAS 439085-51-5)
- Peptide Impurity (CAS CATO-CPTD788810)
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