2-Chloro-5-nitro-N-(4-(quinolin-2-yloxy)phenyl)benzamide CAS 647852-85-5
| CAS No. | 647852-85-5 |
| Molecular Formula | C22H14ClN3O4 |
| Molecular Weight | 419.82 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-5-nitro-N-(4-(quinolin-2-yloxy)phenyl)benzamide (CAS 647852-85-5), molecular formula C22H14ClN3O4 and molecular weight 419.82 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 2-Chloro-5-nitro-N-(4-(quinolin-2-yloxy)phenyl)benzamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 419.82 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-5-nitro-N-(4-(quinolin-2-yloxy)phenyl)benzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H14ClN3O4 |
| Molecular Weight | 419.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 7-Chloro-10-ethyl-3-(4-(trifluoromethyl)phenyl)-3,4-dihydroacridine-1,9(2H,10H)-dione (CAS 144128-99-4)
- 2-(4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)phenoxy)-1-(p-tolyl)ethan-1-one (CAS 339020-07-4)
- N-(4-chloro-3-nitrophenyl)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetamide (CAS 892158-25-7)
- 2-Chloro-N-[2-(2-dimethylamino-5-trifluoromethyl-pyridin-3-yl)-phenyl]-benzamide (CAS 1311278-03-1)
- 4-Chloro-N-[4-(6-dimethylamino-4-trifluoromethyl-pyridin-2-yl)-phenyl]-benzamide (CAS 1311278-32-6)
- 4-Chloro-N-[3-(2-dimethylamino-5-trifluoromethyl-pyridin-3-yl)-phenyl]-benzamide (CAS 1311278-87-1)
- N-(4-Chloro-phenyl)-4-(6-dimethylamino-4-trifluoromethyl-pyridin-2-yl)-benzamide (CAS 1311278-88-2)
- N-(4-Chloro-phenyl)-3-(6-dimethylamino-4-trifluoromethyl-pyridin-2-yl)-benzamide (CAS 1311279-60-3)
Recommended Standards
- 2-(2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetamido)ethyl 4-chlorobenzoate (CAS 379699-19-1)
- 1076235-04-5 PAW9EP9BXO CBS-9106 UNII-PAW9EP9BXO SL-801 1-((6-Chloro-5-(trifluoromethyl)-2-pyridinyl)amino)-3-((3,3-dimethylbutoxy)methyl)-4-methyl-1H-pyrrole-2,5-dione (CAS 1076235-04-5)
- (1E,4E)-1-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}-5-(dimethylamino)penta-1,4-dien-3-one (CAS 1164556-97-1)
- Ochratoxin TA (CAS 53011-67-9)
- 1-([1,1'-Biphenyl]-4-yl)-3-((4-fluorophenyl)amino)propan-1-one (CAS 279672-36-5)
- N-methyl-N-(6-methylpicolinoyl)glycine (CAS 953901-06-9)
- (2-Cyclopentylpyrimidin-5-yl)boronic acid (CAS 2225175-92-6)
- 2-Bromo-6-(difluoromethyl)-3-methylpyridine (CAS 1805222-74-5)
- 3,3,7,7-Tetraethyl-5-(trifluoromethyl)-4,6-dioxa-3,7-disilanonane (CAS 1922958-20-0)
- 2-Morpholinothioacetamide (CAS 16888-43-0)
- 3-Chloro-4-cyclohexylaniline (CAS 62115-76-8)
- 2-[(5-Bromo-3-methyl-2-pyridinyl)(ethyl)amino]-1-ethanol (CAS 1219967-91-5)
- Tert-butyl bromoacetate-2-<SUP>13</SUP>C (CAS 1173022-29-1)
- Liraglutide Impurity 13 TFA Salt (CAS CATO-C4X-199213)
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