Bosutinib Impurity 28 CAS 65182-98-1
| CAS No. | 65182-98-1 |
| Molecular Formula | C9H9Cl2NO2 |
| Molecular Weight | 234.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Bosutinib Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Bosutinib Impurity 28 (CAS 65182-98-1) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9Cl2NO2 and a molecular weight of 234.08 g/mol.
The molecular framework of Bosutinib Impurity 28 (C9H9Cl2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C9H9Cl2NO2 |
| Molecular Weight | 234.08 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Bosutinib Standards
- Bosutinib Impurity N5 (CAS 263149-10-6)
- Bosutinib Impurity N3 (CAS 17722-32-6)
- Bosutinib Impurity 6 (CAS 1156068-41-5)
- Bosutinib Impurity N1 (CAS 879644-03-8)
- Bosutinib Impurity 9 (CAS 92878-95-0)
- Bosutinib Impurity 26 (CAS 67669-19-6)
- Bosutinib Impurity 27 (CAS CATO-C4X-184727)
- Bosutinib Impurity 7 (CAS 142072-71-7)
Recommended Standards
- Clopidogrel Impurity 75 (CAS 1217999-35-3)
- Opicapone impurity 37 (CAS CATO-C4X-240437)
- Clopidogrel Impurity 74 (CAS 1008008-56-7)
- Opicapone impurity 38 (CAS CATO-C4X-240438)
- Cholic Acid Impurity 4 (CAS CATO-C4X-11604)
- Celecoxib Impurity 67 (CAS 910303-54-7)
- Ozanimod Impurity 19 (CAS 2251699-84-8)
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- 2-Amino-4-phenylnicotinic acid (CAS 1707373-13-4)
- N-[4-(4-Benzylpiperazin-1-yl)phenyl]pentanamide (CAS 400075-64-1)
- 7-Bromo-3-cyanoacetylindol (CAS 1171917-33-1)
- tert-Butyl 5-cyano-3-(hydroxymethyl)-1H-indole-1-carboxylate (CAS 914349-11-4)
- Liraglutide (13-21) TFA Salt (CAS CATO-C4X-19928)
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