Nintedanib Impurity 185 CAS 652140-07-3

Description

Compared with other compounds in its class, the molecular weight of 276.38 g/mol gives Nintedanib Impurity 185 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Nintedanib Impurity 185 (CAS 652140-07-3) is a certified pharmaceutical impurity reference standard with the molecular formula C15H24N4O and a molecular weight of 276.38 g/mol.

The molecular framework of Nintedanib Impurity 185 (C15H24N4O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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