7-Chloro-1,3,4,5-tetrahydro-4-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one CAS 65267-29-0
| CAS No. | 65267-29-0 |
| Molecular Formula | C16H15ClN2O2 |
| Molecular Weight | 302.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
7-Chloro-1,3,4,5-tetrahydro-4-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (CAS 65267-29-0), molecular formula C16H15ClN2O2 and molecular weight 302.76 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 7-Chloro-1,3,4,5-tetrahydro-4-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (C16H15ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 302.76 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 7-Chloro-1,3,4,5-tetrahydro-4-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15ClN2O2 |
| Molecular Weight | 302.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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Recommended Standards
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- Diazepam Impurity 1 (CAS 36020-94-7)
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- 2-((5-Bromopyridin-3-yl)oxy)ethanamine (CAS 1112983-17-1)
- 3-(2-Chlorophenoxymethyl)-1-benzofuran-2-carboxylic acid (CAS 1039891-11-6)
- 1-Propyl-1h-pyrazol-3-amine (CAS 956393-73-0)
- 1,3,5-Tris(1,1-dimethylethyl)hexahydro-1,3,5-triazine (CAS 10560-39-1)
- Methyl 2-amino-4-bromo-5-fluorobenzoate (CAS 1395493-30-7)
- 3-Amino-4-hydroxytetrahydrothiophene 1,1-dioxide hydrochloride (CAS 98019-18-2)
- Ethyl 1-((chloromethyl)sulfonyl)piperidine-3-carboxylate (CAS 1341478-68-9)
- 1-(4-Bromophenyl)-2-((2-hydroxyethyl)thio)ethan-1-one (CAS 63987-99-5)
- 4,6-Difluoropyridine-2-carboxylic acid sodium salt (CAS 2173991-61-0)
- Des-Pro-Pro-Tirzepatide (CAS CATO-CPTD788696)
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