Bicalutamide EP Impurity D CAS 654-70-6
| CAS No. | 654-70-6 |
| Molecular Formula | C8H5F3N2 |
| Molecular Weight | 186.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 186.13 g/mol gives Bicalutamide EP Impurity D distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Bicalutamide EP Impurity D (CAS 654-70-6), a pharmacopoeial impurity reference standard (molecular formula C8H5F3N2, MW 186.13 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, Bicalutamide EP Impurity D is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 186.13 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Bicalutamide EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5F3N2 |
| Molecular Weight | 186.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Bicalutamide Standards
- Bicalutamide Impurity 39 (CAS 1448876-90-1)
- Bicalutamide Impurity 19 (CAS 50986-83-9)
- Bicalutamide Impurity 23 (CAS 74926-87-7)
- Bicalutamide Impurity 40 (CAS CATO-C4X-101340)
- Bicalutamide Impurity 9 (CAS 393-36-2)
- Bicalutamide Impurity 13 (CAS 90357-53-2)
- Bicalutamide Impurity 22 (CAS 405-31-2)
- Bicalutamide EP Impurity M (CAS 151262-57-6)
Recommended Standards
- 2-Amino-4-(trifluoromethyl)benzonitrile (CAS 1483-54-1)
- 4-Fluoro-2-methoxy-5-nitroaniline (CAS 1075705-01-9)
- Ethyl 3-hydroxy-4,4,4-trifluorobutyrate Ethyl 4,4,4-trifluoro-3-hydroxybutyrate Ethyl 3-hydroxy-4,4,4-trifluorobutanoate 4,4,4-Trifluoro-3-hydroxybutyric acid ethyl ester 372-30-5 (CAS 372-30-5)
- (3,5-Dimethylphenyl)phosphonic acid (CAS 111192-80-4)
- Tenofovir Impurity 82 (CAS CATO-C4X-107682)
- Esmolol Impurity 86 (CAS CATO-C4X-189186)
- Triamcinolone Acetonide Impurity 52 (CAS 3028309-43-2)
- 3-Methyl-1,5-dioxaspiro[5.5]Undecan-3-amine (CAS 17144-64-8)
- 3-(Furan-2-yl)-4-propyl-1h-pyrazol-5-amine (CAS 1229025-36-8)
- ethyl (E)-3-hydroxy-2-tetrahydropyran-4-yl-prop-2-enoate (CAS 2308512-34-5)
- 6-Chloro-3-(4-chlorophenyl)pyridazine-4-carboxylic acid (CAS 1437433-87-8)
- Tert-butyl 5-amino-2-methoxybenzoate (CAS 194025-90-6)
- Cefradine Impurity 26 (CAS CATO-C4X-121526)
- Mast Cell Degranulating Peptide HR-1 (CAS 80533-94-4)
Why CATO?
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