Alogliptin Impurity 49 CAS 655-63-0
| CAS No. | 655-63-0 |
| Molecular Formula | C8H5Br2N |
| Molecular Weight | 274.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Alogliptin Impurity 49 (CAS 655-63-0), a pharmacopoeial impurity reference standard (molecular formula C8H5Br2N, MW 274.94 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Alogliptin Impurity 49 (C8H5Br2N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 274.94 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5Br2N |
| Molecular Weight | 274.94 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Alogliptin Standards
- Alogliptin Impurity 99 (CAS 256386-07-9)
- Alogliptin Impurity 17 (CAS 865758-96-9)
- Alogliptin Impurity 27 (CAS CATO-C4X-109927)
- Alogliptin Impurity 28 (CAS CATO-C4X-109928)
- Alogliptin Impurity 59 (CAS CATO-C4X-109959)
- Alogliptin Impurity 60 (CAS 2514763-78-9)
- Alogliptin Impurity 44-d3 (CAS 1794937-18-0)
- Alogliptin Impurity 50 (CAS 1883825-48-6)
Recommended Standards
- Imatinib Impurity 42 (CAS 67013-55-2)
- tert-Butyl dibromocarbamate (CAS 358365-86-3)
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- Methadone Impurity 18 (CAS 748166-19-0)
- Papaverine impurity 21 (CAS CATO-C4X-206721)
- Atorvastatin Impurity 103 (CAS 1797905-42-0)
- Relmapirazin impurity 10 (CAS CATO-C4X-333410)
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- rel-((3R,4S)-Benzyl 3-fluoro-4-hydroxypiperidine-1-carboxylate) (CAS 913574-95-5)
- Tert-butyl 1-(hydroxymethyl)-2-azabicyclo[4.1.0]Heptane-2-carboxylate (CAS 2306269-96-3)
- 2-(5-Phenyl-1H-pyrazol-3-yl)acetic acid (CAS 919198-86-0)
- Ethyl 4-hydroxy-2,3-dihydro-1H-indene-2-carboxylate (CAS 136191-20-3)
- 4-(3-Fluorobenzyl)tetrahydro-2h-pyran-4-carboxylic acid (CAS 1380300-75-3)
- Peptide Fmoc-Thi-Thi-OH (CAS CATO-CPTD788552)
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