Asenapine impurity 2 CAS 65621-78-5
| CAS No. | 65621-78-5 |
| Molecular Formula | C17H16ClNO |
| Molecular Weight | 285.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Asenapine impurity 2 (CAS 65621-78-5) is a certified pharmaceutical impurity reference standard with the molecular formula C17H16ClNO and a molecular weight of 285.77 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Asenapine impurity 2 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 285.77 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C17H16ClNO |
| Molecular Weight | 285.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Asenapine Standards
Recommended Standards
- Metoclopramide Impurity 68 (CAS 101385-94-8)
- Bilastine impurity 86 (CAS CATO-C4X-225386)
- Metoclopramide EP Impurity F (CAS 38339-95-6)
- Chlorphenamine Impurity 73 (CAS CATO-C4X-118873)
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- Cefdinir Impurity 99 (CAS CATO-C4X-121099)
- Thioctic acid Impurity 93 (CAS 102561-84-2)
- N-Nitroso Nipecotic Acid (CAS 65445-62-7)
- 2-methyl-4-(1H-pyrrol-3-yl)-1,3-thiazole (CAS 1803583-12-1)
- Methyl (1-(4-chlorophenyl)cyclopropane-1-carbonyl)glycinate (CAS 1147472-86-3)
- Azetidin-1-yl(5-bromopyridin-2-yl)methanone (CAS 845306-16-3)
- 3-Amino-6-(difluoromethyl)-4-methylthieno[2,3-b]pyridine-2-carbonitrile (CAS 942358-78-3)
- 1,1-Isophthaloylbiscaprolactam (CAS 7381-13-7)
- Serpent Peptide (CAS 823202-99-9)
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