Metoclopramide EP Impurity F CAS 38339-95-6
| CAS No. | 38339-95-6 |
| Molecular Formula | C13H20ClN3O2 |
| Molecular Weight | 285.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 285.77 g/mol gives Metoclopramide EP Impurity F distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Metoclopramide EP Impurity F (CAS 38339-95-6, C13H20ClN3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H20ClN3O2, Metoclopramide EP Impurity F contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 285.77 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H20ClN3O2 |
| Molecular Weight | 285.77 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Metoclopramide Standards
- Metoclopramide Impurity 68 (CAS 101385-94-8)
- Metoclopramide Impurity 66 (CAS CATO-C4X-141566)
- Metoclopramide impurity 48 (CAS CATO-C4X-141548)
- Metoclopramide impurity 53 (CAS CATO-C4X-141553)
- Metoclopramide Impurity 15 (CAS CATO-C4X-141515)
- Metoclopramide Impurity 76 (CAS CATO-C4X-141576)
- Metoclopramide Impurity 107 (CAS CATO-C4X-1415107)
- Metoclopramide Impurity 27 (CAS CATO-C4X-141527)
Recommended Standards
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- Hydrocortisone Impurity 70 (CAS 116816-20-7)
- Brivaracetam Impurity 154 TFA (CAS CATO-C4X-2007154)
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- Betamethasone EP Impurity G (CAS 85700-75-0)
- 1-(Benzylthio)propan-2-one (CAS 10230-69-0)
- (R)-3-((tert-Butyldimethylsilyl)oxy)propane-1,2-diol (CAS 63121-18-6)
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