2-Chloro-5-(trifluoromethyl)benzoic Acid CAS 657-06-7
| CAS No. | 657-06-7 |
| Molecular Formula | C8H4ClF3O2 |
| Molecular Weight | 224.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C8H4ClF3O2, 2-Chloro-5-(trifluoromethyl)benzoic Acid contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 224.56 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
2-Chloro-5-(trifluoromethyl)benzoic Acid (CAS 657-06-7), molecular formula C8H4ClF3O2 and molecular weight 224.56 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF3O2 |
| Molecular Weight | 224.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-(3-Chloro-4-fluorophenyl)-2,2-difluoroacetic acid (CAS 1027514-19-7)
- 2-Chloro-4-(trifluoromethoxy)benzaldehyde (CAS 1079351-20-4)
- 5-Chloro-2-(trifluoromethoxy)benzaldehyde (CAS 1092461-15-8)
- 3-Chloro-4-(trifluoromethyl)benzoic Acid (CAS 115754-20-6)
- Methyl 3-chloro-2,4,5-trifluorobenzoate (CAS 1214375-02-6)
- 4-Chloro-2-(trifluoromethoxy)benzaldehyde (CAS 1261442-48-1)
- 3-Chloro-2-(trifluoromethoxy)benzaldehyde (CAS 1261498-32-1)
- 2-Chloro-6-(trifluoromethoxy)benzaldehyde (CAS 1261822-56-3)
Recommended Standards
- 2-Chloro-5-(trifluoromethoxy)benzaldehyde (CAS 468075-02-7)
- 2-Chloro-6-(trifluoromethyl)benzoic Acid (CAS 2376-00-3)
- 2-Chloro-4-(trifluoromethyl)benzoic acid (CAS 23228-45-7)
- 3-(Chloro-difluoro-methoxy)-benzoyl fluoride (CAS 39161-74-5)
- Ethyl 4-(dimethylamino)-5-fluoro-8-methylquinoline-3-carboxylate (CAS 1315345-89-1)
- N-phenyl-N-((trichloromethyl)thio)benzenesulfonamide (CAS 2280-49-1)
- Tert-butyl (S)-6-oxohexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate (CAS 2412856-87-0)
- 4-Chloro-N-(6-nitrobenzo[d]thiazol-2-yl)benzamide (CAS 321943-75-3)
- Benzo[d][1,3]dioxole-2-carboxylic acid (CAS 827-81-6)
- 2-Bromo-1-(5-fluoro-2-methoxy-3-nitrophenyl)ethan-1-one (CAS 683274-82-0)
- tert-Butyl thiazolo[4,5-b]pyridin-2-ylcarbamate (CAS 1934834-74-8)
- 3-Formylphenyl 2,4-dichlorobenzoate (CAS 443737-22-2)
- 6-Methyl-5H-imidazo[4,5-d][1,2,3]triazin-4-amine (CAS 500285-68-7)
- (His32,Leu34)-Neuropeptide Y (32-36) (CAS 168916-68-5)
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