4-(Trifluoromethyl)piperidine 4-Trifluoromethylpiperidine 657-36-3 EBD23253 CAS 657-36-3
| CAS No. | 657-36-3 |
| Molecular Formula | C6H10F3N |
| Molecular Weight | 153.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(Trifluoromethyl)piperidine 4-Trifluoromethylpiperidine 657-36-3 EBD23253 (C6H10F3N) is characterized by fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4-(Trifluoromethyl)piperidine 4-Trifluoromethylpiperidine 657-36-3 EBD23253 (CAS 657-36-3), molecular formula C6H10F3N and molecular weight 153.15 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H10F3N |
| Molecular Weight | 153.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 1-(Trifluoromethyl)cyclopentanamine (CAS 1202965-57-8)
- (R)-2-(Trifluoromethyl)piperidine (CAS 1212734-83-2)
- 1260678-84-9 2-(Trifluoromethyl)cyclopentanamine 2-(trifluoromethyl)cyclopentan-1-amine (CAS 1260678-84-9)
- (3R)-3-(Trifluoromethyl)piperidine (CAS 1282530-77-1)
- 3-(Trifluoromethyl)cyclopentan-1-amine (CAS 1334146-43-8)
- 2-[1-(trifluoromethyl)cyclopropyl]ethan-1-amine (CAS 1369100-74-2)
- 2-methyl-2-(trifluoromethyl)pyrrolidine (CAS 141519-24-6)
- [3-(Trifluoromethyl)cyclobutyl]methanamine (CAS 1461707-85-6)
Recommended Standards
- 3862-73-5 Benzenamine, 2,3,4-trifluoro- Benzenamine, 2,3,4-trifluoro-C198 2,3,4-Trifluoroaniline 4-12-00-01114 (Beilstein Handbook Reference) Aniline, 2,3,4-trifluoro- BRN 3245609 EC 407-170-9 (CAS 3862-73-5)
- 3-(Trifluoromethyl)piperidine hydrochloride 768-31-0 C6H11ClF3N MFCD02183561 (CAS 768-31-0)
- 4-(Trifluoromethyl)pyridine 4-trifluoromethylpyridine 4-trifluoromethyl-pyridine 3796-24-5 (CAS 3796-24-5)
- 3-Fluoroacetanilide (CAS 351-28-0)
- 1-(2-Chlorophenyl)-4-hexylpiperazine (CAS 866151-38-4)
- 2-oxabicyclo[2.1.1]hexan-4-ylmethanamine;hydrochloride (CAS 2287280-60-6)
- 2-(chloromethyl)cyclopropane-1-carboxylic acid (CAS 1779806-94-8)
- 4-Bromo-1-(pyridin-4-ylmethyl)pyridin-2(1h)-one (CAS 2090429-68-6)
- ethyl 2-fluoro-1H-imidazole-5-carboxylate (CAS 71518-44-0)
- 4-(2-Bromoethoxy)benzene-1-sulfonamide (CAS 125174-28-9)
- 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazol-2(3H)-one (CAS 1613639-44-3)
- (R)-1-(3-(Difluoromethyl)phenyl)ethan-1-amine hydrochloride (CAS 2230840-55-6)
- N-(2-ethoxybenzyl)ethanamine (CAS 869942-06-3)
- Tirzepatide Impurity 26 X TFA Salt (CAS CATO-C4X-324026)
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