Piperacillin EP Impurity D CAS 65772-67-0
| CAS No. | 65772-67-0 |
| Molecular Formula | C39H44N8O10S2 |
| Molecular Weight | 848.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Piperacillin EP Impurity D is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Piperacillin EP Impurity D (CAS 65772-67-0, C39H44N8O10S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Piperacillin EP Impurity D (C39H44N8O10S2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C39H44N8O10S2 |
| Molecular Weight | 848.94 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 22.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Nitrogen Atoms | 8 |
| Sulfur Atoms | 2 |
Related Piperacillin Standards
- Piperacillin Impurity 74 (CAS CATO-C4X-173274)
- Piperacillin EP Impurity R (CAS CATO-C4X-173225)
- Piperacillin Impurity 78 (CAS CATO-C4X-173278)
- Piperacillin Impurity 28 (CAS CATO-C4X-173228)
- Piperacillin Impurity 83 (CAS CATO-C4X-173283)
- Piperacillin impurity 104 (CAS CATO-C4X-1732104)
- Piperacillin Dimer Impurity 68 (CAS CATO-C4X-173268)
- Piperacillin impurity 93 (CAS CATO-C4X-173293)
Recommended Standards
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