5-(Trifluoromethyl)furan-2-carbonyl chloride CAS 65865-25-0
| CAS No. | 65865-25-0 |
| Molecular Formula | C6H2ClF3O2 |
| Molecular Weight | 198.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 5-(Trifluoromethyl)furan-2-carbonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
5-(Trifluoromethyl)furan-2-carbonyl chloride (CAS 65865-25-0) is a high-purity analytical reference standard with the molecular formula C6H2ClF3O2 and a molecular weight of 198.53 g/mol.
Based on its molecular formula C6H2ClF3O2, 5-(Trifluoromethyl)furan-2-carbonyl chloride contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 198.53 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C6H2ClF3O2 |
| Molecular Weight | 198.53 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F/Cl-containing |
Related Trifluoromethyl Standards
- 3-(Trifluoromethyl)-1H-pyrazole-5-carbonyl chloride (CAS 129768-29-2)
- 6-(trifluoromethyl)imidazo[2,1-b]thiazole (CAS 109113-98-6)
- 5-(trifluoromethyl)pyridazine-3-carboxylic acid (CAS 1211535-95-3)
- 3-(Trifluoromethyl)-1,8-naphthyridine (CAS 1261365-77-8)
- 2-[4-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (CAS 1341347-35-0)
- 2-(Trifluoromethyl)quinoxaline (CAS 148853-42-3)
- 4-(Trifluoromethyl)tetrahydro-2H-pyran-4-carboxylic acid (CAS 1524761-14-5)
- 5-(Trifluoromethyl)quinazoline (CAS 16499-47-1)
Recommended Standards
- 2-Chloro-4-(trifluoromethyl)pyrimidin-5-ol (CAS 1805229-04-2)
- 5-Chloro-4-(trifluoromethyl)pyridazin-3(2H)-one (CAS 2820002-76-2)
- Pyrazine Impurity 5 (CAS 1803596-66-8)
- 5-Chloro-4-(trifluoromethyl)pyrimidin-2(1H)-one (CAS 785777-96-0)
- 2-Neopentyl-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (CAS 1707735-70-3)
- tert-butyl 4-formyl-7-methyl-5-(trideuteriomethoxy)indole-1-carboxylate (CAS 1481631-52-0)
- Clovoxamine-d3 (CAS 1185246-59-6)
- N'-(2-(1H-pyrrol-1-yl)benzoyl)benzenesulfonohydrazide (CAS 31739-64-7)
- 3-(Furan-2-ylmethyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one (CAS 902434-07-5)
- methyl 2-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)acetate (CAS 1803583-26-7)
- 2-[(2-Chloro-5-fluoro-4-pyrimidinyl)amino]ethanol (CAS 16255-90-6)
- Olopatadine Impurity 22 (CAS 4174-84-9)
- 2-amino-3-(piperidin-1-yl)propan-1-ol dihydrochloride (CAS 1803605-69-7)
- Semaglutide impurity 193 (CAS CATO-C4X-2226193)
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