Olopatadine Impurity 22 CAS 4174-84-9
| CAS No. | 4174-84-9 |
| Molecular Formula | C21H23NP |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Olopatadine Impurity 22 (CAS 4174-84-9) is a certified pharmaceutical impurity reference standard with the molecular formula C21H23NPHBrBr and a molecular weight of 481.21 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, organophosphorus functionality, bromine substitution, Olopatadine Impurity 22 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 481.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H23NP HBr Br |
| Molecular Weight | 481.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Olopatadine Standards
- Olopatadine Impurity 44 (CAS 111088-69-8)
- Olopatadine Impurity 43 (CAS 1127893-02-0)
- Olopatadine Methyl Ester HCl (CAS 113805-71-3（free base）)
- Olopatadine Impurity 51 (CAS 113806-01-2)
- Olopatadine Ethyl Ester (HCl) (CAS 113806-03-4)
- Olopatadine (CAS 113806-05-6)
- (E)-Olopatadine (CAS 113806-06-7)
- Olopatadine Impurity N3 (CAS 113835-76-0)
Recommended Standards
- Sovateltide Impurity 2 (CAS CATO-C4X-34652)
- Bedaquiline Impurity 20 (CAS CATO-C4X-116720)
- Isavuconazole Impurity 138 (CAS 2962831-00-9)
- 4-Methoxybenzyl (E)-(2-(furan-2-yl)vinyl)carbamate (CAS 338399-75-0)
- 3-Bromo-3',3''-difluorotrityl alcohol (CAS 845790-82-1)
- 4-(Benzo[d]thiazol-2-yl)-1-(4-fluorophenyl)-1H-1,2,3-triazol-5-amine (CAS 1032226-33-7)
- Ethyl 6-(methylamino)hexanoate hydrochloride (CAS 65498-93-3)
- 3,3',4',5,5'-Pentachloro-[1,1'-biphenyl]-4-ol (CAS 130689-92-8)
- n-[3-(1h-1,3-benzodiazol-2-yl)propyl]-2-methylpropanamide (CAS 637322-75-9)
- Fibrinopeptide A (human) (CAS 25422-31-5)
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