Piroxicam EP Impurity B CAS 65897-46-3
| CAS No. | 65897-46-3 |
| Molecular Formula | C14H11N3O4S |
| Molecular Weight | 317.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Piroxicam EP Impurity B (CAS 65897-46-3) is a certified pharmaceutical impurity reference standard with the molecular formula C14H11N3O4S and a molecular weight of 317.32 g/mol.
Structurally, Piroxicam EP Impurity B (C14H11N3O4S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 317.32 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Piroxicam EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H11N3O4S |
| Molecular Weight | 317.32 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Piroxicam Standards
- Piroxicam Impurity 19 (CAS CATO-C4X-173319)
- Piroxicam (CAS 36322-90-4)
- Piroxicam Impurity 27 (CAS 1184017-37-5)
- Piroxicam D3 (N-methyl D3) (CAS 942047-64-5)
- Piroxicam EP Impurity L(Meloxicam EP Impurity F) (CAS 118854-48-1)
- Piroxicam Impurity 20 (CAS CATO-C4X-173320)
- Piroxicam Impurity 16 (CAS 1797884-12-8)
- Piroxicam Impurity 25 (CAS CATO-C4X-173325)
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