2-Bromo-6-(trifluoromethoxy)-4-(trifluoromethyl)quinoline-3-carboxylic acid CAS 663193-37-1
| CAS No. | 663193-37-1 |
| Molecular Formula | C12H4BrF6NO3 |
| Molecular Weight | 404.06 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-Bromo-6-(trifluoromethoxy)-4-(trifluoromethyl)quinoline-3-carboxylic acid (CAS 663193-37-1), a certified reference material (molecular formula C12H4BrF6NO3, MW 404.06 g/mol) for analytical method development and quality control.
The molecular framework of 2-Bromo-6-(trifluoromethoxy)-4-(trifluoromethyl)quinoline-3-carboxylic acid (C12H4BrF6NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H4BrF6NO3 |
| Molecular Weight | 404.06 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- Methyl 4-bromo-3-(3-bromo-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxylate (CAS 1439441-56-1)
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- 2-Bromo-4-((2,4-dichlorobenzyl)oxy)-5-ethoxybenzaldehyde (CAS 832674-02-9)
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Recommended Standards
- N,N'-(ethene-1,2-diyl)bis(2,5-dichlorobenzamide) (CAS CATO-C4X-31672)
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- 1-(2,4,6-Trichlorophenyl)-3-(2-chloro-5-aminoanilino)-5-pyrazolone (CAS 86491-51-2)
- 3-(Benzyloxy)-6-bromo-4-iodo-2-methylpyridine (CAS 2796279-98-4)
- n-(4-(2-(Propylamino)ethyl)phenyl)acetamide (CAS 1310257-87-4)
- 2-chloro-N-(2-hydroxy-2-methylpropyl)acetamide (CAS 1477831-75-6)
- (2S)-2-(Ethoxymethyl)oxirane (CAS 734107-45-0)
- (S)-2-Acetamido-3-mercaptopropanamide (CAS 10061-64-0)
- 4,4'-Bis(2-methylthiazol-4-yl)-1,1'-biphenyl (CAS 113090-48-5)
- 1-(5-(Trifluoromethyl)pyridin-2-yl)azetidin-3-ol (CAS 874832-39-0)
- 5-Methyl-6,7-dihydro-2H-pyrrolo[3,4-c]pyridin-4(5H)-one (CAS 358732-62-4)
- 2-(3-Chloro-2,6-difluorophenyl)acetonitrile (CAS 261762-55-4)
- (S)-N-Cyclopentyl-N-(3,5-dimethylbenzyl)pyrrolidin-3-amine (CAS 820980-01-6)
- D-[Asp]9-Semaglutide (CAS CATO-CPTD788631)
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