2-(2-(Furan-2-yl)vinyl)-1-(3-(trifluoromethyl)phenyl)quinazolin-4(1H)-one CAS 66486-01-9
| CAS No. | 66486-01-9 |
| Molecular Formula | C21H13F3N2O2 |
| Molecular Weight | 382.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(2-(Furan-2-yl)vinyl)-1-(3-(trifluoromethyl)phenyl)quinazolin-4(1H)-one (C21H13F3N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
2-(2-(Furan-2-yl)vinyl)-1-(3-(trifluoromethyl)phenyl)quinazolin-4(1H)-one (CAS 66486-01-9), molecular formula C21H13F3N2O2 and molecular weight 382.34 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(2-(Furan-2-yl)vinyl)-1-(3-(trifluoromethyl)phenyl)quinazolin-4(1H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H13F3N2O2 |
| Molecular Weight | 382.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 3-(2-Spiroadamantane)-4-Methoxy-4-(3- (CAS 122341-56-4)
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- Vericiguat impurity 56 (CAS CATO-C4X-289656)
- 2-Thiophenepropanoic acid, 4-bromo-β-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]-β-methyl-, methyl ester, (βS)- (CAS 917777-02-7)
- (R)-2-(2-Nitrobenzyl)piperazine (CAS 1240582-86-8)
- (2S,3S)-2-(1-ethyl-1H-imidazol-2-yl)tetrahydro-2H-pyran-3-amine dihydrochloride (CAS 1820579-90-5)
- 7-Methoxy-N4-(3-vinylphenyl)quinazoline-4,6-diamine (CAS 2044704-89-2)
- 2-Chloro-5-(5-iodo-1,2-oxazol-3-yl)pyridine (CAS 2092543-98-9)
- 6'-[3-(Trifluoromethyl)phenyl]-2,4-dihydrospiro[1-benzopyran-3,3'-[1,5]dioxane]-4-one (CAS 339029-02-6)
- WIN 552,12-3 Mesylate (CAS 131543-25-4)
- 4-Methyl-2-pivalamidonicotinic Acid (CAS 2006278-17-5)
- (3-Bromopropyl)diethylamine hydrobromide (CAS 69835-35-4)
- 3’-Bromo-4’-methoxyacetophenone (CAS 35310-75-9)
- (Cys2)-Neuropeptide Y-8-aminooctanoyl-(D-Cys27)-Neuropeptide Y (25-32) (H-3298.0500) (CAS 128806-04-2)
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