Brexpiprazole Impurity 18 CAS 66490-33-3
| CAS No. | 66490-33-3 |
| Molecular Formula | C8H5ClS |
| Molecular Weight | 168.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Brexpiprazole Impurity 18.
CATO supplies Brexpiprazole Impurity 18 (CAS 66490-33-3), a pharmacopoeial impurity reference standard (molecular formula C8H5ClS, MW 168.64 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Brexpiprazole Impurity 18 (C8H5ClS) is characterized by sulfur-containing functionality, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Brexpiprazole Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5ClS |
| Molecular Weight | 168.64 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Brexpiprazole Standards
- Brexpiprazole impurity 108 (CAS 17082-09-6)
- Brexpiprazole Impurity 53 (CAS 102-92-1)
- Brexpiprazole Impurity 70 (CAS 6940-78-9)
- Brexpiprazole Impurity 89 (CAS 15450-69-8)
- Brexpiprazole Impurity 15 (CAS 31570-97-5)
- Brexpiprazole Impurity 4 (CAS 70500-72-0)
- Brexpiprazole impurity 121 (CAS CATO-C4X-1131121)
- Brexpiprazole Impurity 152 (CAS 1602255-57-1)
Recommended Standards
- 26394-17-2 Cyclopentanesulfonyl chloride cyclopentanesulphonyl chloride (CAS 26394-17-2)
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- Ethyl 2-chloro-2-(methylthio)acetate (CAS 56078-31-0)
- 1-Butyl-4-chlorobenzene (CAS 15499-27-1)
- Apalutamide impurity 91 (CAS CATO-C4X-274991)
- Finerenone Impurity 198 (CAS 1097097-47-6)
- Ibrutinib Impurity N2 (CAS 43191-23-7)
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- 6-(Pyridin-2-yl)pyridazine-3-thiol (CAS 1005036-25-8)
- D-Pro31-Tirzepatide (CAS CATO-CPTD788905)
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