Brexpiprazole Impurity 4 CAS 70500-72-0
| CAS No. | 70500-72-0 |
| Molecular Formula | C9H7NO2 |
| Molecular Weight | 161.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Brexpiprazole Impurity 4.
As a process- or degradation-related impurity, Brexpiprazole Impurity 4 (CAS 70500-72-0, C9H7NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Brexpiprazole Impurity 4 (C9H7NO2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 161.16 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7NO2 |
| Molecular Weight | 161.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Nitrogen Atoms | 1 |
Related Brexpiprazole Standards
- Brexpiprazole Impurity 15 (CAS 31570-97-5)
- Brexpiprazole Impurity 89 (CAS 15450-69-8)
- Brexpiprazole impurity 108 (CAS 17082-09-6)
- Brexpiprazole Impurity 53 (CAS 102-92-1)
- Brexpiprazole Impurity 18 (CAS 66490-33-3)
- Brexpiprazole Impurity 70 (CAS 6940-78-9)
- Brexpiprazole Impurity 31 (CAS 95-15-8)
- Brexpiprazole impurity 121 (CAS CATO-C4X-1131121)
Recommended Standards
- Adefovir Impurity 12 (CAS 20245-85-6)
- Felodipine Impurity 15 (CAS 21962-45-8)
- Bedaquiline impurity 44 (CAS 93499-67-3)
- Rivaroxaban impurity 194 (CAS CATO-C4X-1090194)
- Pitavastatin Impurity 73 (CAS CATO-C4X-103773)
- Quetiapine Fumarate EP Impurity V (CAS 2204369-14-0)
- Selexipag Impurity 18 (CAS CATO-C4X-196118)
- ethyl 2-[3-(aminomethyl)phenyl]-4-methyl-1,3-thiazole-5-carboxylate hydrochloride (CAS 1803601-77-5)
- (2S,6S)-2,6-Dibenzyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole (CAS 877773-30-3)
- 2-(Benzyloxy)benzyl acetate (CAS 1073234-31-7)
- 2-(2-Amino-2-oxoethyl)isoquinolin-2-ium chloride (CAS 78572-48-2)
- 2-(4-Fluorophenyl)-1-(4-iodophenyl)ethan-1-one (CAS 898784-87-7)
- n-(3-(Benzyl(methyl)amino)propyl)-1h-imidazole-1-carboxamide (CAS 1087788-39-3)
- Semaglutide impurity 99 (CAS CATO-C4X-222699)
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