2-Amino-6-(hydroxymethyl)-4-(3-methoxy-4-propoxyphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile CAS 664999-51-3
| CAS No. | 664999-51-3 |
| Molecular Formula | C20H20N2O6 |
| Molecular Weight | 384.38 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-Amino-6-(hydroxymethyl)-4-(3-methoxy-4-propoxyphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile (CAS 664999-51-3), molecular formula C20H20N2O6 and molecular weight 384.38 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Amino-6-(hydroxymethyl)-4-(3-methoxy-4-propoxyphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile (C20H20N2O6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C20H20N2O6 |
| Molecular Weight | 384.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 2-Amino-6-(hydroxymethyl)-4-(4-isopropoxy-3-methoxyphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile (CAS 674805-37-9)
- 5-((4-(((2-Amino-9H-purin-6-yl)oxy)methyl)benzyl)amino)-5-oxopentanoic acid (CAS 881663-34-9)
- 2-Amino-4-trifluoromethylphenyl Disulfide (CAS 7038-40-6)
- (R)-2-Amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butanoic acid (CAS 53276-26-9)
- 9,9-Bis(4-amino-3-fluorophenyl)fluorene (CAS 127926-65-2)
- 5-Amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-imidazole-4-carboxamide (CAS 23274-21-7)
- 2-Amino-4-(5-ethoxy-4-isopropoxycyclohexa-1,3-dien-1-yl)-7-methyl-5-oxo-4H,5H-pyrano[4,3-b]pyran-3-carbonitrile (CAS 625375-61-3)
- 2-((4-Amino-5-(tert-butyl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-bromophenyl)acetamide (CAS 540498-84-8)
Recommended Standards
- 2-[2-(3,4-Diacetoxy-phenyl)-vinyl]-6-methoxy-benzoic acid methyl ester (CAS 365543-25-5)
- 2-(4-(2-(Trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxamide (CAS 916888-66-9)
- 3-(3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)naphthalene-1,5-disulfonic acid (CAS 6838-01-3)
- 2-((3-(3,4-Dimethoxyphenyl)-2-methyl-4-oxo-4H-chromen-7-yl)oxy)acetohydrazide (CAS 844859-04-7)
- Eltrombopag lactose adduct (CAS CATO-C4X-119854)
- 1-Methoxy-4-isoquinolinecarboxaldehyde (CAS 1005772-69-9)
- 2-(3-(Trifluoromethoxy)phenyl)piperazine (CAS 910444-43-8)
- 3-Amino-5,8-diphenyl-1,2,4-triazocine (CAS 109367-42-2)
- N-(3-hydroxyphenyl)-3-oxobutanamide (CAS 22016-03-1)
- 4-(((2-Aminoethyl)(methyl)amino)methyl)benzonitrile (CAS 1250429-03-8)
- Methyl (R)-2-((tert-butoxycarbonyl)amino)-3-(5-hydroxy-1H-indol-3-yl)propanoate (CAS 1234880-33-1)
- 3-[(4-methoxyphenoxy)methyl]aniline (CAS 1016523-59-3)
- 2-[(2-Chloro-6-fluorophenyl)methyl]-4-[(1E)-{[(pyridin-4-yl)methyl]imino}methyl]benzene-1,3-diol (CAS 341967-49-5)
- MOTS-c Peptide (CAS 1627580-64-6)
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