2-[(2,6-difluorophenyl)formamido]acetic acid CAS 66648-38-2
| CAS No. | 66648-38-2 |
| Molecular Formula | C9H7F2NO3 |
| Molecular Weight | 215.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 215.15 g/mol gives 2-[(2,6-difluorophenyl)formamido]acetic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 2-[(2,6-difluorophenyl)formamido]acetic acid (CAS 66648-38-2), a certified reference material (molecular formula C9H7F2NO3, MW 215.15 g/mol) for analytical method development and quality control.
The molecular framework of 2-[(2,6-difluorophenyl)formamido]acetic acid (C9H7F2NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7F2NO3 |
| Molecular Weight | 215.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related difluorophenyl Standards
- 2-[(2,4-difluorophenyl)methylamino]-2-Oxoacetic Acid (CAS 1248263-78-6)
- 1-(3,4-Difluorophenyl)-3-nitro-1-propanone (CAS 1345413-22-0)
- 3-(2,6-difluorophenyl)-2-methyl-2-nitrooxirane (CAS 1909319-31-8)
- 2-[(2,4-difluorophenyl)formamido]acetic acid (CAS 918157-04-7)
- 2-[(3,4-difluorophenyl)formamido]acetic acid (CAS 315707-69-8)
- 2-[(3,5-difluorophenyl)formamido]acetic acid (CAS 923691-92-3)
- Methyl 2-[(2,4-difluorophenyl)amino]-2-oxoacetate (CAS 480450-76-8)
- 2-(3,4-Difluorophenyl)-2-(ethylamino)acetic acid (CAS 1214017-87-4)
Recommended Standards
- 1-((Trifluoromethyl)sulfinyl)pyrrolidine-2,5-dione (CAS 569337-23-1)
- 4,4,5,5-tetramethyl-2-(2,3,4,5,6-pentadeuteriophenyl)-1,3,2-dioxaborolane (CAS 245043-33-8)
- (4-(Difluoromethoxy)benzo[d]oxazol-2-yl)methanol (CAS 1806342-74-4)
- 4-Allyl-2,3,5,6-tetrafluorobenzonitrile (CAS 94220-31-2)
- (2-Ethyl-oxazol-5-yl)-methanol (CAS 1312601-18-5)
- (1S,5R,6S)-5-Hydroxy-3-((S)-1-hydroxy-3-methylbut-2-en-1-yl)-7-oxabicyclo[4.1.0]hept-3-en-2-one (CAS 31298-54-1)
- (2E)-3-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-phenylprop-2-en-1-one (CAS 1025208-97-2)
- Dapagliflozin Impurity 82 (CAS 461432-27-9)
- (2S,3S,5S)-5-tert-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane succinate (2s,3s,5s)-2-amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane hemi succinic acid salt (2s,3s,5s)-2-amino-3-hydroxy-5-(tert-butyloxy carbonyl)amino-1,6-diphenylhexane succinate (2s,3s,5s)-5-tert-butyloxycarbonylamino-2-amino -3-hydroxy -1,6-diphenylhexane 1/2 succinate 183388-64-9 BDH succinate salt (CAS 183388-64-9)
- (1H-Imidazo[4,5-b]pyridin-6-yl)methanamine (CAS 267876-24-4)
- 5,8-Dimethoxy-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline (CAS 1267035-14-2)
- Chloromethyl 3,3-dimethylbutanoate (CAS 114670-75-6)
- N-Hexyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-phenylacetamide (CAS 62347-15-3)
- Semaglutide Impurity 143 (CAS CATO-C4X-2226143)
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