Dapagliflozin Impurity 82 CAS 461432-27-9
| CAS No. | 461432-27-9 |
| Molecular Formula | C21H25ClO7 |
| Molecular Weight | 424.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dapagliflozin Impurity 82 (CAS 461432-27-9) is a certified pharmaceutical impurity reference standard with the molecular formula C21H25ClO7 and a molecular weight of 424.87 g/mol.
The molecular framework of Dapagliflozin Impurity 82 (C21H25ClO7) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H25ClO7 |
| Molecular Weight | 424.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
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Recommended Standards
- Sotagliflozin Impurity 2 (CAS 1327165-94-5)
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- 6-Bromo-4-(chloromethyl)-5-fluorophthalazin-1(2H)-one (CAS 2836223-99-3)
- VU 29 N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide 890764-36-0 (CAS 890764-36-0)
- 2-Bromo-3-(bromomethyl)benzaldehyde (CAS 1261724-75-7)
- 4-(2-methoxyphenyl)-6-methyl-isoxazolo[5,4-b]pyridin-3-amine (CAS 1226227-45-7)
- Neuropeptide W-23 (rat) (CAS 383415-89-2)
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