6-Chloro-4-methylnicotinonitrile CAS 66909-35-1
| CAS No. | 66909-35-1 |
| Molecular Formula | C7H5ClN2 |
| Molecular Weight | 152.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 6-Chloro-4-methylnicotinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
6-Chloro-4-methylnicotinonitrile (CAS 66909-35-1), molecular formula C7H5ClN2 and molecular weight 152.58 g/mol, is a CATO reference standard with documented purity and traceability.
6-Chloro-4-methylnicotinonitrile (C7H5ClN2) contains a nitrile group, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C7H5ClN2 |
| Molecular Weight | 152.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 3-Chloro-1H-pyrrolo[3,2-c]pyridine (CAS 1000342-65-3)
- 2-(2-Chloro-4-pyridyl)acetonitrile (CAS 1000565-45-6)
- 2-(2-Chloro-3-pyridyl)acetonitrile (CAS 101012-32-2)
- 4-Chloro-2-cyano-6-methylpyridine, 97% (CAS 104711-65-1)
- Methyl 4-chloro-3-hydroxybutanoate (CAS 10488-68-3)
- 5-Chloro-2-ethynylpyridin-3-amine (CAS 1150617-82-5)
- 2-Chloro-1H-pyrrolo[2,3-b]pyridine (CAS 1174936-85-6)
- 4-Chloro-6-azaindole (CAS 1188313-15-6)
Recommended Standards
- 6-Chloro-1H-pyrrolo[3,2-c]pyridine (CAS 74976-31-1)
- 6-Chloro-4-methylpyridine-2-carbonitrile (CAS 209858-74-2)
- 5-Chloroimidazo[1,2-a]pyridine (CAS 63111-79-5)
- 6-Chloro-5-methylnicotinonitrile (CAS 66909-33-9)
- tert-Butyl N-[(3S)-pyrrolidin-3-yl]carbamate hydrochloride (CAS 1416450-61-7)
- 3-Methyl-1-[2-(2-piperidinyl)ethyl]piperidinedihydrochloride (CAS 1219957-51-3)
- 2-(3,5-Dimethyl-1H-pyrazol-4-yl)-N-methylethan-1-amine dihydrochloride (CAS 423176-42-5)
- 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-N-methylethan-1-amine sulfate (CAS 1262770-79-5)
- 1-(3-Chlorophenyl)-3-(1-hydroxy-2-methylpropan-2-yl)urea (CAS 522660-64-6)
- 5-Bromo-2-(3,3-difluoropyrrolidin-1-yl)benzonitrile 1627693-40-6 (CAS 1627693-40-6)
- (2S,6R)-1-(2-methoxyethyl)-2,6-dimethylpiperazine (CAS 1909293-60-2)
- 8-((4-Nitrophenyl)thio)quinoline (CAS 1873-66-1)
- 1-(1,3-Thiazol-4-yl)ethane-1,2-diol (CAS 1598034-97-9)
- Acetyl Hexapeptide-38 (CAS 1400634-44-7)
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