3-Amino-6-chloro-4-picoline CAS 66909-38-4
| CAS No. | 66909-38-4 |
| Molecular Formula | C6H7ClN2 |
| Molecular Weight | 142.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Amino-6-chloro-4-picoline.
3-Amino-6-chloro-4-picoline (CAS 66909-38-4) is a high-purity analytical reference standard with the molecular formula C6H7ClN2 and a molecular weight of 142.59 g/mol.
The molecular framework of 3-Amino-6-chloro-4-picoline (C6H7ClN2) is characterized by a nitrile group, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Amino-6-chloro-4-picoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H7ClN2 |
| Molecular Weight | 142.59 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 5-Amino-2-(chloromethyl)pyridine (CAS 1140241-24-2)
- 2-Amino-4-chloro-3-methylpyridine (CAS 1227595-52-9)
- 3-Amino-2-chloro-4-methylpyridine (CAS 133627-45-9)
- 2-Amino-3-chloro-5-picoline (2-Amino-3-chloro-5-methylpyridine) (CAS 31430-41-8)
- 2-Amino-5-chloro-3-methylpyridine (CAS 20712-16-7)
- 2-Amino-5-chloro-4-methylpyridine (CAS 36936-27-3)
- 2-Amino-6-chloro-4-methylpyridine (CAS 51564-92-2)
- 3-Amino-2-chloro-6-picoline (CAS 39745-40-9)
Recommended Standards
- 3-Amino-5-chloro-2-methylpyridine (CAS 89639-36-1)
- 3-Chloro-1,2-benzenediamine (CAS 21745-41-5)
- 3-Chloro-2,5-dimethylpyrazine (CAS 95-89-6)
- 3-(Chloromethyl)pyridin-4-amine (CAS 887584-31-8)
- 1-(2,2-Dimethylthiomorpholino)-2-methylpropan-1-one (CAS 1592587-56-8)
- 4’-Methoxy-2-chloroacetophenone (CAS 2196-99-8)
- 5-Chloro-4-(chlorosulfonyl)-2-methoxybenzoic acid (CAS 1375472-16-4)
- 2-(3-Methylbutyl)-2-(propan-2-yl)propane-1,3-diol (CAS 129228-29-1)
- 1-(2-Phenoxyethyl)piperazine dimethanesulfonate (CAS 1609399-72-5)
- 2-Methyltryptamine Oxalate (CAS 859040-56-5)
- N-(cyclohexylmethyl)-1-methylpyrrolidin-3-amine (CAS 1249247-00-4)
- N'-[(1E)-{4-[(2,4-dichlorophenyl)methoxy]phenyl}methylidene]-2-phenylacetohydrazide (CAS 329777-94-8)
- (4-(4-Chlorophenyl)thiazol-2-yl)methanamine dihydrochloride (CAS 1332528-71-8)
- D-Ile27-Tirzepatide (CAS CATO-CPTD788907)
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