2-Chloro-1-methyl-1H-indole-3-carbonyl chloride CAS 67342-12-5
| CAS No. | 67342-12-5 |
| Molecular Formula | C10H7Cl2NO |
| Molecular Weight | 228.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Chloro-1-methyl-1H-indole-3-carbonyl chloride (C10H7Cl2NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
2-Chloro-1-methyl-1H-indole-3-carbonyl chloride (CAS 67342-12-5) is a high-purity analytical reference standard with the molecular formula C10H7Cl2NO and a molecular weight of 228.07 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-Chloro-1-methyl-1H-indole-3-carbonyl chloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H7Cl2NO |
| Molecular Weight | 228.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 6-Chloro-3-(chloromethyl)quinolin-2(1H)-one (CAS 1017127-45-5)
- 7-Chloro-3-(chloromethyl)quinolin-2(1H)-one (CAS 1017161-81-7)
- 2-Chloro-1-(6-chloro-1h-indol-3-yl)ethan-1-one (CAS 1018637-67-6)
- 2-Chloro-1-(5-chloro-1H-indol-2-yl)ethan-1-one (CAS 1799477-12-5)
- 3-Chloro-2-(chloromethyl)quinolin-4-ol (CAS 856100-78-2)
- 6-Chloro-2-(chloromethyl)-4(1H)-quinolinone (CAS 946784-67-4)
- 8-Chloro-2-(chloromethyl)quinolin-4-ol (CAS 946692-43-9)
- 3-Chloro-4-(4-chloro-1h-pyrazol-1-yl)aniline (CAS 1006959-51-8)
Recommended Standards
- 2,7-Dichloro-8-methoxyquinoline (CAS 928627-13-8)
- 3-(chloromethyl)-5-(2-chlorophenyl)-1,2-oxazole (CAS 339019-69-1)
- 2,6-Dichloro-4-methoxyquinoline (CAS 952434-99-0)
- 3-(Chloromethyl)-5-(4-chlorophenyl)-1,2-oxazole (CAS 343374-64-1)
- 1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-4-hydroxypiperidine-4-carboxylic acid (CAS 1854926-85-4)
- 2-Ethyl-5-fluoro-4-methoxybenzaldehyde (CAS 1234845-81-8)
- 2,3-Dimethoxy-6,7-dimethyl-1-propylnaphthalene (CAS 213971-41-6)
- 3-(3-Chloropyridin-4-yl)propan-1-ol (CAS 1493086-34-2)
- Methyl 3-amino-4,4-dimethylpentanoatehydrochloride (CAS 1272758-12-9)
- 6-Chloro-1H-pyrazolo[3,4-b]pyridin-3-amine (CAS 1352909-30-8)
- Gatifloxacin Dimer 4 (CAS 1497338-53-0)
- N-Adamantan-2-yl-2-chloro-acetamide (CAS 103951-51-5)
- Methyl 1-acetamido-3-cyclohexene-1-carboxylate (CAS 172299-70-6)
- Tau Peptide (294-305) (human) trifluoroacetate salt (CAS 1428135-29-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com