Mavacamten Impurity 9 CAS 67463-81-4
| CAS No. | 67463-81-4 |
| Molecular Formula | C12H21N3O3 |
| Molecular Weight | 255.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Mavacamten Impurity 9.
Mavacamten Impurity 9 (CAS 67463-81-4) is a certified pharmaceutical impurity reference standard with the molecular formula C12H21N3O3 and a molecular weight of 255.31 g/mol.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Mavacamten Impurity 9 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 255.31 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H21N3O3 |
| Molecular Weight | 255.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Nitrogen Atoms | 3 |
Related Mavacamten Standards
- Mavacamten (CAS 1642288-47-8)
- Mavacamten Impurity 4 (CAS 1642288-94-5)
- Mavacamten Impurity 5 (CAS 1642288-64-9)
- Mavacamten-D5 (CAS 2453251-00-6)
- Mavacamten Impurity 19 (CAS CATO-C4X-298219)
- Mavacamten Impurity 11 (CAS 1642289-43-7)
- Mavacamten Impurity 15 (CAS 30221-94-4)
- Mavacamten Impurity 10 (CAS 1642289-54-0)
Recommended Standards
- Nefopam impurity 25 (CAS CATO-C4X-283725)
- Brompheniramine impurity 5 (CAS CATO-C4X-29985)
- Coumarin 102 (CAS 41267-76-9)
- Elacestrant Impurity 3 (CAS 722519-59-7)
- Daunorubicin EP Impurity B ((S)-Isomer) (CAS 28008-55-1)
- Atrasentan Impurity 151 (CAS 1058403-94-3)
- Letermovir Impurity 91 (CAS CATO-C4X-291591)
- Dimethyl sulfoxide-<SUP>13</SUP>C<SUB>2</SUB> (CAS 136321-15-8)
- 5-((Tetrahydro-2H-pyran-4-yl)oxy)picolinic acid (CAS 1393330-58-9)
- (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,3-dimethoxyphenyl)propanoic acid (CAS 1260618-81-2)
- 3-Amino-N-cyclopropyl-4-(1H-imidazol-1-yl)benzamide (CAS 924851-82-1)
- 2-Methyl-1-(m-tolyl)cyclohexan-1-ol (CAS 97704-28-4)
- 6-Chloro-1H-indazole-4-carbonitrile (CAS 1425932-59-7)
- Peptide 46 (H-4054.0500) (CAS 192122-40-0)
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