2-(2H-1,3-Benzodioxole-5-carbonyl)-6-(furan-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-3-amine CAS 674807-15-9
| CAS No. | 674807-15-9 |
| Molecular Formula | C20H11F3N2O4S |
| Molecular Weight | 432.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(2H-1,3-Benzodioxole-5-carbonyl)-6-(furan-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-3-amine (CAS 674807-15-9), molecular formula C20H11F3N2O4S and molecular weight 432.37 g/mol, is a CATO reference standard with documented purity and traceability.
2-(2H-1,3-Benzodioxole-5-carbonyl)-6-(furan-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-3-amine (C20H11F3N2O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H11F3N2O4S |
| Molecular Weight | 432.37 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related H Standards
- 3-[1-(2H-1,3-Benzodioxole-5-carbonyl)piperidin-4-yl]-4-[(4-methoxyphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775380-33-0)
- 1-(2H-1,3-Benzodioxole-5-carbonyl)-4-{[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine (CAS 1775399-14-8)
- 3-[1-(2H-1,3-Benzodioxole-5-carbonyl)piperidin-4-yl]-4-[(4-methylphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775558-61-6)
- 2-(2H-1,3-Benzodioxole-5-carbonyl)-6-methyl-4-(thiophen-2-yl)-5H,6H,7H,8H-thieno[2,3-b]1,6-naphthyridin-3-amine (CAS 354555-88-7)
- 3-(1,3-Benzodioxole-5-Carbonyl)-5-Fluoro-1-[(2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Pyrimidine-2,4-Dione (CAS 74234-11-0)
- 1-(2H-1,3-Benzodioxole-5-carbonyl)-4-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]piperidine (CAS 352033-96-6)
- 2-(2H-1,3-Benzodioxole-5-carbonyl)-6-ethyl-5H,6H,7H,8H-thieno[2,3-b]quinolin-3-amine (CAS 625370-69-6)
- 2-(2H-1,3-Benzodioxole-5-carbonyl)-6-(3,4-dimethoxyphenyl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-3-amine (CAS 625369-53-1)
Recommended Standards
- (E)-2-(allylthio)-1-benzyl-1H-imidazole-5-carbaldehyde O-(2,4-dichlorobenzyl) oxime (CAS 320423-18-5)
- 3-Iodo-5-isopropoxy-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole (CAS 2092913-79-4)
- 4-((4-(4-Nitro-2-(trifluoromethyl)phenoxy)phenyl)sulfonyl)morpholine (CAS 1858242-18-8)
- 4-Bromo-N-(2-((4-fluorobenzyl)thio)-2-methylpropyl)benzenesulfonamide (CAS 339104-26-6)
- 3-Iodo-7-methoxyquinoline (CAS 1260640-72-9)
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- 4-(Cyclopentylmethyl)tetrahydro-2h-pyran-4-carboxylic acid (CAS 1342667-52-0)
- (R)-2-(1-methylpyrrolidin-2-yl)acetic acid hydrochloride (CAS 1174655-95-8)
- 6-Bromo-5-fluoro-1,3,3-trimethylindolin-2-one (CAS 1581753-73-2)
- Imperialine 3- β-D-Glucoside (CAS 67968-40-5)
- Ethyl 1-ethyl-6-hydroxy-1h-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1160246-35-4)
- N-(2-Chloroethyl)-1-imidazolesulfonamide (CAS 195051-72-0)
- 4-(5-Formyl-4-methylpyridin-2-yl)piperazine-1-carbaldehyde (CAS 1355182-54-5)
- Semaglutide Impurity 11 (CAS CATO-C4X-222611)
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