6-(Trifluoromethyl)pyridine-3-thiol CAS 677772-36-0
| CAS No. | 677772-36-0 |
| Molecular Formula | C6H4F3NS |
| Molecular Weight | 179.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-(Trifluoromethyl)pyridine-3-thiol.
6-(Trifluoromethyl)pyridine-3-thiol (CAS 677772-36-0), molecular formula C6H4F3NS and molecular weight 179.16 g/mol, is a CATO reference standard with documented purity and traceability.
6-(Trifluoromethyl)pyridine-3-thiol (C6H4F3NS) contains a nitrile group, sulfur-containing functionality, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-(Trifluoromethyl)pyridine-3-thiol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4F3NS |
| Molecular Weight | 179.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Trifluoromethyl Standards
- 2-(Trifluoromethyl)pyridine-4-thiol (CAS 1093954-03-0)
- 6-(Trifluoromethyl)pyridine-2-thiol (CAS 121307-80-0)
- 2-(Trifluoromethyl)pyridine-3-thiol (CAS 1801693-48-0)
- 3-(Trifluoromethyl)pyridine-4-thiol (CAS 1806316-97-1)
- 2-[(trifluoromethyl)sulfanyl]pyridine (CAS 57830-49-6)
- 3-((Trifluoromethyl)thio)pyridine (CAS 58313-26-1)
- 5-(Trifluoromethyl)pyridine-2(1H)-thione (CAS 76041-72-0)
- 5-(Trifluoromethyl)pyridine-3-thiol (CAS 912545-82-5)
Recommended Standards
- 6-(difluoromethyl)pyridine-3-carboxylic acid (CAS 913091-98-2)
- Ethyl 3,3-difluoropyrrolidine-2-carboxylate (CAS 779301-37-0)
- Methyl (S)-4,4-difluoropiperidine-2-carboxylate (CAS 750563-70-3)
- 2-Amino-4,5-difluorobenzoic acid 2-amino-4,5-difluoro 2-amino-4,5-difluorobenzoic acid,4,5-difluoroanthranilic acid 2-carboxy-4,5-difluoroaniline, 4,5-difluoroanthranilic acid 4,5-Difluoroanthranilic acid 4,5-difluoroanthranilic acid (2-amino-4,5-difluorobenzoic acid) 83506-93-8 benzoicacid, 2-amino-4,5-difluoro- buttpark 49\07-41 (CAS 83506-93-8)
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