Dopamine Impurity 16 CAS 67992-45-4
| CAS No. | 67992-45-4 |
| Molecular Formula | C8H7NO2 |
| Molecular Weight | 149.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Dopamine Impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Dopamine Impurity 16 (CAS 67992-45-4, C8H7NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dopamine Impurity 16 (C8H7NO2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H7NO2 |
| Molecular Weight | 149.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Nitrogen Atoms | 1 |
Related Dopamine Standards
Recommended Standards
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- Cetilistat Impurity 5 (CAS 22876-16-0)
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- Regorafenib Impurity 60 (CAS CATO-C4X-104760)
- 2-Isopropylquinazolin-4-ol (CAS 13182-64-4)
- Methyl 5-amino-3-chloropyrazine-2-carboxylate (CAS 34617-66-8)
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- 4'-((7-Hydroxy-5-propylpyrazolo[1,5-a]pyrimidin-6-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid (CAS 167375-28-2)
- 4-Bromo-3-methyl-1-tosyl-1H-pyrrole-2-carbaldehyde (CAS 1284257-69-7)
- 6-(4-Cyanophenyl)imidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide (CAS 550366-69-3)
- Semaglutide impurity 94 (CAS CATO-C4X-222694)
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