Remimazolam Impurity 12 CAS 308243-65-4
| CAS No. | 308243-65-4 |
| Molecular Formula | C21H19BrN4O2 |
| Molecular Weight | 439.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Remimazolam Impurity 12.
As a process- or degradation-related impurity, Remimazolam Impurity 12 (CAS 308243-65-4, C21H19BrN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Remimazolam Impurity 12 (C21H19BrN4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Remimazolam Impurity 12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H19BrN4O2 |
| Molecular Weight | 439.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Remimazolam Standards
- Remimazolam Impurity 11 (CAS CATO-C4X-282311)
- Remimazolam Impurity 17 (CAS CATO-C4X-282317)
- Remimazolam Impurity 2 (CAS 960305-91-3)
- Remimazolam Impurity 14 (CAS CATO-C4X-282314)
- Remimazolam Impurity 5 (CAS 1276185-51-3)
- Remimazolam Impurity 10 (CAS CATO-C4X-282310)
- Remimazolam Impurity 13 (CAS CATO-C4X-282313)
- Remimazolam Impurity 1 (CAS 1275616-59-5)
Recommended Standards
- (4-(3,6-Diphenyl-9H-carbazol-9-yl)phenyl)boronic acid (CAS 607739-93-5)
- Pyrazolynate (CAS 58011-68-0)
- Cefminox Impurity 48 (CAS CATO-C4X-192648)
- 5-(4-Bromophenyl)-1-(4-(difluoromethoxy)phenyl)-2-(isopropylthio)-1H-imidazole (CAS 1226427-26-4)
- Clonazepam Impurity 5 (CAS 17714-02-2)
- Tadalafil Impurity 153 (CAS CATO-C4X-1087153)
- Ertapenem impurity 46 (CAS CATO-C4X-163346)
- bis(4-ethoxyphenyl)amine (CAS CATO-C3D-263216)
- 2-((2-Bromophenyl)amino)propanehydrazide (CAS 1396994-66-3)
- (S)-2-Amino-2-(4-bromophenyl)ethan-1-ol hydrochloride (CAS 2095773-02-5)
- Telmisartan-d7 (CAS 1794754-60-1)
- Travoprost Impurity 57 (CAS CATO-C4X-192557)
- 6-Aminooctahydropyrido[1,2-b][1,2,6]thiadiazine 1,1-dioxide (CAS 2758149-25-4)
- Calcium-Like Peptide 3 (CAS 261969-05-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com