5-Acetylthiophene-2-carboxamide(Arotinolol Impurity 7) CAS 68257-89-6
| CAS No. | 68257-89-6 |
| Molecular Formula | C7H7NO2S |
| Molecular Weight | 169.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C7H7NO2S, 5-Acetylthiophene-2-carboxamide(Arotinolol Impurity 7) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 169.20 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
5-Acetylthiophene-2-carboxamide(Arotinolol Impurity 7) (CAS 68257-89-6) is a certified pharmaceutical impurity reference standard with the molecular formula C7H7NO2S and a molecular weight of 169.20 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7NO2S |
| Molecular Weight | 169.20 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Acetylthiophene Standards
- 3-Acetylthiophene-2-carboxylic acid (CAS 13657-90-4)
- 4-Acetylthiophene-2-carboxylic acid (CAS 88105-23-1)
- 5-Acetylthiophene-3-carboxylic acid (CAS 33148-86-6)
- 3-Acetylthiophene-2-carbaldehyde (CAS 16363-90-9)
- 4-Acetylthiophene-2-carbaldehyde (CAS 37815-63-7)
- 5-Acetylthiophene-2-carbaldehyde (CAS 4565-29-1)
- Methyl 3-acetylthiophene-2-carboxylate (CAS 88105-18-4)
- Methyl 5-acetylthiophene-3-carboxylate (CAS 88770-21-2)
Recommended Standards
- Edoxaban Impurity 111 (CAS CATO-C4X-1063111)
- Dotinurad Impurity 24 (CAS 4433-53-8)
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- Nicotinic Acid-2-Methylmercapto (CAS 74470-23-8)
- Norethisterone EP Impurity H (CAS 51724-44-8)
- Vardenafil Hydrochloride Trihydrate EP Impurity C (CAS 1255919-03-9)
- Rivaroxaban Impurity 7(R-isomer) (CAS 181140-34-1)
- 1-(2-Iodophenyl)cyclopropane-1-carboxylic acid (CAS 124276-93-3)
- 4-amino-1,2,5-thiadiazole-3-carboxamide hydrochloride (CAS 856657-74-4)
- 3,4-Dichloropyridine methanesulfonate (CAS 1215561-47-9)
- 2-(2-Bromothiazol-5-yl)ethanamine (CAS 910401-29-5)
- 3-(Difluoromethyl)-5-methoxypicolinic acid (CAS 1805007-54-8)
- 3-Bromo-5-chloro-6-methylpyrazine-2-carbonitrile (CAS 1065266-98-9)
- Sperm Activating Peptide, Sea Urchin (CAS 140653-27-6)
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