Rivaroxaban Impurity 7(R-isomer) CAS 181140-34-1
| CAS No. | 181140-34-1 |
| Molecular Formula | C11H9NO3 |
| Molecular Weight | 203.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 203.19 g/mol gives Rivaroxaban Impurity 7(R-isomer) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Rivaroxaban Impurity 7(R-isomer) (CAS 181140-34-1) is a certified pharmaceutical impurity reference standard with the molecular formula C11H9NO3 and a molecular weight of 203.19 g/mol.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Rivaroxaban Impurity 7(R-isomer) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 203.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H9NO3 |
| Molecular Weight | 203.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Nitrogen Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 7(S-isomer) (CAS 161596-47-0)
- Rivaroxaban Impurity 32 (CAS 956904-18-0)
- Rivaroxaban Impurity 108 (CAS CATO-C4X-1090108)
- Rivaroxaban Impurity 122 (CAS CATO-C4X-1090122)
- Rivaroxaban Impurity 49 (CAS 1224684-98-3)
- Rivaroxaban Impurity 105 (CAS 1261222-08-5)
- Rivaroxaban Impurity 107 (CAS 482308-13-4)
- Rivaroxaban Impurity 134 (CAS 36157-41-2)
Recommended Standards
- Moxifloxacin impurity 165 (CAS 457948-35-5)
- Moxifloxacin impurity 164 (CAS 1668584-26-6)
- Indacaterol Impurity 5 (CAS 62978-73-8)
- Moxifloxacin impurity 163 (CAS 148887-46-1)
- Rupatadine Impurity 4 (CAS 1235342-53-6)
- Crisaborole lmpurity 78 (CAS 2251695-12-0)
- Chlortetracycline EP Impurity G (CAS 769895-23-0)
- 1-Benzyl-5-chloro-6-oxo-N-phenyl-1,6-dihydropyridine-3-carboxamide (CAS 339024-32-7)
- Ethyl 4-amino-4-methylpentanoate hydrochloride (CAS 2206264-52-8)
- 5-Methoxy-1H-pyrrolo[2,3-c]pyridin-2(3H)-one (CAS 878483-98-8)
- Tert-butyl (3-carbamoylthietan-3-yl)carbamate (CAS 2002183-97-1)
- Isavuconazole Impurity 226 (CAS CATO-C4X-1236226)
- 2-(2-Mercapto-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)-N-(2-methylphenyl)acetamide (CAS 1142200-44-9)
- (2S)-2-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine (2S)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyryl-L-alanyl-L-alanine 2-Amino-4-(methylphosphino)butyrylalanylalanine 35597-43-4 Antibiotic SF 1293 Bialaphos CHEBI:3088 L-phosphinothricyl-L-alanyl-L-alanine N-{(2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoyl}-L-alanyl-L-alanine PTT Phosphinothricylalanylalanine bilanafos gamma-(Hydroxymethylphosphinyl)-L-alpha-aminobutyryl-L-alanyl-L-alanine phosphinothricin tripeptide (CAS 35597-43-4)
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