Glimepiride EP Impurity A CAS 684286-46-2
| CAS No. | 684286-46-2 |
| Molecular Formula | C24H34N4O5S |
| Molecular Weight | 490.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 490.62 g/mol gives Glimepiride EP Impurity A distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Glimepiride EP Impurity A (CAS 684286-46-2) is a certified pharmaceutical impurity reference standard with the molecular formula C24H34N4O5S and a molecular weight of 490.62 g/mol.
Glimepiride EP Impurity A (C24H34N4O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H34N4O5S |
| Molecular Weight | 490.62 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Glimepiride Standards
- Glimepiride EP Impurity D (CAS 791104-62-6)
- Glimepiride EP Impurity I (CAS 878480-70-7)
- Glimepiride (CAS 93479-97-1)
- Glimepiride-d4 (CAS 1131981-29-7)
- Glimepiride EP Impurity H (CAS CATO-C4X-11028)
- Glimepiride Impurity 26 (CAS CATO-C4X-110226)
- Glimepiride Impurity 10 (CAS 600177-94-4)
- Glimepiride Impurity 12 (CAS 318515-70-7)
Recommended Standards
- CAS 1406-18-4 (CAS 1406-18-4)
- PF-3758309 (CAS 898044-15-0)
- Dimethyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)-5-formylterephthalate (CAS 2830605-44-0)
- 5-{[2-(2-{[1-(4-methylbenzenesulfonyl)-1H-indol-4-yl]oxy}ethoxy)ethyl]sulfanyl}-1,3,4-thiadiazol-2-amine (CAS 478040-20-9)
- Isavuconazole Impurity N8 (CAS 241479-75-4)
- Ceftolozane impurity 45 (CAS CATO-C4X-240645)
- Cefmetazole Impurity 64 (CAS CATO-C4X-150764)
- Sixantphos (CAS 166330-11-6)
- N-(4-(dimethylamino)phenyl)thiophene-2-carboxamide (CAS 349133-54-6)
- Remdesivir Impurity 19 (CAS 1355049-95-4)
- Fexofenadine EP Impurity G (CAS 1187954-57-9)
- 3-Cyano-6-hydroxypyridone Sodium Salt (CAS 91467-46-8)
- 4-(5-Bromo-2-nitrophenyl)morpholine 1396780-21-4 (CAS 1396780-21-4)
- Insulin Degludec Impurity 12 (CAS CATO-C4X-215712)
Why CATO?
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