2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[3-(propan-2-yloxy)phenyl]acetamide CAS 685107-49-7
| CAS No. | 685107-49-7 |
| Molecular Formula | C17H16ClF3N2O2 |
| Molecular Weight | 372.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[3-(propan-2-yloxy)phenyl]acetamide (CAS 685107-49-7), molecular formula C17H16ClF3N2O2 and molecular weight 372.77 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[3-(propan-2-yloxy)phenyl]acetamide (C17H16ClF3N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 372.77 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H16ClF3N2O2 |
| Molecular Weight | 372.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)ethyl)-N-methyl-2-phenylacetamide (CAS 337919-77-4)
- 2-Chloro-3-(2,4-dioxopentan-3-yl)-1,4-dihydroxyanthracene-9,10-dione (CAS 89607-90-9)
- 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl 3,3-dimethylbutan-2-yl methylphosphonate (CAS 875577-99-4)
- 4-((5-Chloro-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)oxy)-3-methoxybenzoic acid (CAS 881463-44-1)
- 4-Chloro-N-(3-(4-fluorobenzyl)-4-hydroxy-2-oxopyridin-1(2H)-yl)benzamide (CAS 477846-11-0)
- N-(3-Chloro-4-methoxyphenyl)-3-nitro-4-(1H-pyrazol-1-yl)benzamide (CAS 321570-91-6)
- Methyl 2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfonyl}-3-(dimethylamino)prop-2-enoate (CAS 1823194-70-2)
- 7-Chloro-N-[3-(trifluoromethyl)phenyl]-3,4-dihydro-2H-1,4-benzothiazine-4-carboxamide (CAS 338777-90-5)
Recommended Standards
- 2-(4-Chlorophenyl)-5-phenyl-3-(trifluoromethyl)benzofuran (CAS 821770-02-9)
- 1-(4-Chlorobenzyl)-3-phenyl-1-(3,3,3-trifluoro-2-hydroxypropyl)urea (CAS 478258-83-2)
- PF-6274484 (CAS 1035638-91-5)
- Roxadustat Glycine (CAS 808116-60-1)
- 3-Amino-4-(3,4-dimethoxyphenyl)-N-mesityl-6-(p-tolyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 443740-34-9)
- 2-((4-Chlorobenzyl)thio)-6-methyl-4-(thiophen-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carbonitrile (CAS 387831-24-5)
- Ethyl 4-((2-ethoxy-2-oxoethyl)thio)butanoate (CAS 63449-37-6)
- Ethyl 4-methoxy-3,5-dimethylbenzoate (CAS 105401-94-3)
- 2-Nitro-3-trifluoromethoxy-phenylamine (CAS 1261445-43-5)
- 5α-ESTRAN-3α, 17β-DIOL (CAS 10002-95-6)
- N-(1-Phenylethyl)cyclopropanamine (CAS 51586-25-5)
- Regaloside C (CAS 117591-85-2)
- 1-(Chloromethoxy)-3-fluorobenzene (CAS 34888-01-2)
- Neuropeptide Y (2-36) (human, rat) trifluoroacetate salt (CAS 123139-39-9)
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