Etofenamate Impurity N9 CAS 68749-59-7
| CAS No. | 68749-59-7 |
| Molecular Formula | C17H16F3NO2 |
| Molecular Weight | 323.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 323.31 g/mol gives Etofenamate Impurity N9 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Etofenamate Impurity N9 (CAS 68749-59-7), a pharmacopoeial impurity reference standard (molecular formula C17H16F3NO2, MW 323.31 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Etofenamate Impurity N9 (C17H16F3NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H16F3NO2 |
| Molecular Weight | 323.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Etofenamate Standards
- Etofenamate EP Impurity G (CAS 32508-98-8)
- Etofenamate Impurity 10 (CAS CATO-C4X-260310)
- Etofenamate Impurity 9 (CAS CATO-C4X-26039)
- Etofenamate Impurity 11 (CAS CATO-C4X-260311)
- Etofenamate Impurity 13 (CAS CATO-C4X-260313)
- Etofenamate Impurity 12 (CAS CATO-C4X-260312)
- Etofenamate (CAS 30544-47-9)
- Etofenamate Impurity 2 (CAS CATO-C4X-26032)
Recommended Standards
- Ethyl 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-(morpholinomethyl)-1H-1,2,3-triazole-4-carboxylate (CAS 311314-84-8)
- Methyl 3-(4-(1H-tetrazol-1-yl)benzamido)benzoate (CAS 924829-01-6)
- 5-Methyl-1-(4-nitrophenyl)-N-phenyl-1H-1,2,4-triazole-3-carboxamide (CAS 321431-07-6)
- N-(4-Methylphenyl)-3-nitro-4-(1H-1,2,4-triazol-1-yl)benzenecarboxamide (CAS 338407-90-2)
- Dapagliflozin Impurity 172 (CAS CATO-C4X-1138172)
- Crizotinib impurity 20 (CAS CATO-C4X-102520)
- Flurbiprofen Impurity 70 (CAS CATO-C4X-144470)
- 5,7-Dihydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one (CAS 72472-92-5)
- Pyrrolo[2,3-b]pyrrole-1,2,3(6H)-triamine (CAS 877396-86-6)
- 2-(2-(Heptan-3-yloxy)ethoxy)ethan-1-ol (CAS 10138-87-1)
- N-1-Adamantyladamantan-1-amine hydrochloride (CAS 561327-49-9)
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- 3-(3-Bromo-2-methyl-6-(methylsulfonyl)phenyl)-4,5-dihydroisoxazole (CAS 247922-29-8)
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