N-Deacetyl, 1,2,3,10-demethyl Colchicine CAS 6877-18-5
| CAS No. | 6877-18-5 |
| Molecular Formula | C16H15NO5 |
| Molecular Weight | 301.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
N-Deacetyl, 1,2,3,10-demethyl Colchicine (CAS 6877-18-5), molecular formula C16H15NO5 and molecular weight 301.29 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, N-Deacetyl, 1,2,3,10-demethyl Colchicine is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 301.29 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C16H15NO5 |
| Molecular Weight | 301.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related N Standards
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- N-Deacetyl 10-Demethyl Colchicine (CAS 3482-37-9)
- N-Deacetyl Colchicine (CAS 3476-50-4)
- N-Deacetyl-N-Formyl Agomelatine (CAS 138113-05-0)
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Recommended Standards
- N-Carbobenzoxy-4-hydroxy-D-2-phenylglycine (CAS 26787-75-7)
- Ketorolac Impurity 40 (CAS CATO-C4X-166940)
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- Flutriafol (CAS 76674-21-0)
- 1-Benzyl-3-bromopiperidin-4-one (CAS 104860-16-4)
- 3’-Methylbiphenyl-3-carboxylic Acid (CAS 158619-46-6)
- 1-Benzhydryl-N-methylazetidin-3-amine (CAS 69159-49-5)
- rac 2-Myristoyl-3-chloropropanediol, 95% (CAS 1330166-18-1)
- 2-amino-2-(4-hydroxy-3,5-dimethylphenyl)acetic acid (CAS 37409-33-9)
- N-(4-(Dimethylamino)phenyl)-2-((4-ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 618412-18-3)
- trans-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate hydrochloride (CAS 1609403-41-9)
- 2,6-Difluoro-5-methylpyrimidin-4-amine (CAS 18260-66-7)
- 5-Iodoquinoline-8-sulfonic acid (CAS 803634-97-1)
- Palmitoyl Hexapeptide-12 (CAS 171263-26-6)
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