Colchicine Impurity 8 CAS 6877-25-4
| CAS No. | 6877-25-4 |
| Molecular Formula | C21H21NO6 |
| Molecular Weight | 383.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Colchicine Impurity 8 (CAS 6877-25-4) is a certified pharmaceutical impurity reference standard with the molecular formula C21H21NO6 and a molecular weight of 383.39 g/mol.
The molecular framework of Colchicine Impurity 8 (C21H21NO6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO manufactures Colchicine Impurity 8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H21NO6 |
| Molecular Weight | 383.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related Colchicine Standards
- Colchicine EP Impurity A (CAS 7411-12-3)
- Colchicine EP Impurity E (CAS 7336-33-6)
- Colchicine EP Impurity F (CAS 477-27-0)
- Colchicine Impurity 4 (CAS 57866-21-4)
- Colchicine Racemic Mixture Impurity (CAS 54192-66-4)
- rac-Colchicine, >98% (CAS 209810-38-8)
- (R)-Colchicine (CAS 75520-89-7)
- Colchicine EP Impurity B (CAS CATO-C4X-141112)
Recommended Standards
- 60594-55-0 (+-)-beta-Hydrastine (+-)-Hydrastine (CAS 60594-55-0)
- Hydrastine (CAS 118-08-1)
- 29617-43-4 (1S,9R)-beta-Hydrastine DTXSID1045611 (CAS 29617-43-4)
- Tetrabutylstannane-d36 (CAS 358731-92-7)
- Pretomanid Impurity 18 (CAS CATO-C4X-260618)
- Indinavir Sulfate EP Impurity F (CAS 3099-31-8)
- Citalopram Impurity 85 (CAS CATO-C4X-110985)
- Methyl 2-[(piperidin-4-yl)methyl]furan-3-carboxylate hydrochloride (CAS 1134618-26-0)
- N-(3-Methoxyphenyl)-2-methylbenzamide (CAS 55814-35-2)
- Diisopropyl ((3,4-dimethoxyphenyl)(hydroxy)methyl)phosphonate (CAS 67691-79-6)
- (Z)-4-(2-methoxybenzylidene)-2-phenyloxazol-5(4h)-one (CAS 57427-84-6)
- 4-(Furan-2-yl)butan-2-ol (CAS 6963-39-9)
- 1-(Pyridin-2-yl)pyrrolidine-2,5-dione (CAS 33624-29-2)
- [His]1+12-Semaglutide (CAS CATO-C4X-2226178)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com