2'-Bromo-[1,1'-biphenyl]-2-carboxylic acid CAS 69200-16-4
| CAS No. | 69200-16-4 |
| Molecular Formula | C13H9BrO2 |
| Molecular Weight | 277.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2'-Bromo-[1,1'-biphenyl]-2-carboxylic acid.
2'-Bromo-[1,1'-biphenyl]-2-carboxylic acid (CAS 69200-16-4), molecular formula C13H9BrO2 and molecular weight 277.11 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2'-Bromo-[1,1'-biphenyl]-2-carboxylic acid (C13H9BrO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H9BrO2 |
| Molecular Weight | 277.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Br-containing |
Related Bromo Standards
- 3-bromo-4-phenoxybenzaldehyde (CAS 1000414-11-8)
- 2-Bromo-[1,1'-biphenyl]-3-carboxylic acid (CAS 1049143-36-3)
- 2-Bromo-1,4-bis(methoxymethoxy)benzene (CAS 131136-47-5)
- methyl 6-bromo-3-oxo-benzofuran-2-carboxylate (CAS 1403582-72-8)
- 3-Bromo-5-(3,3-difluoropyrrolidin-1-ylmethyl)-pyridine (CAS 1428065-38-6)
- 3-Bromo-5-(4,4-difluoropiperidin-1-yl)pyridine (CAS 1707358-05-1)
- 3-Bromo-4-(3,3-difluoropiperidin-1-yl)pyridine (CAS 1707358-06-2)
- 1707365-66-9 3-Bromo-4-(4,4-difluoropiperidin-1-yl)pyridine (CAS 1707365-66-9)
Recommended Standards
- 2,4-dichloro-7-(trifluoromethyl)quinazoline (CAS 396-02-1)
- 2'-Bromo-[1,1'-biphenyl]-4-carboxylic acid (CAS 3808-94-4)
- 2-(4-Bromophenoxy)benzaldehyde (CAS 364323-77-3)
- 3'-Bromo-[1,1'-biphenyl]-4-carboxylic acid (CAS 5737-83-7)
- 1-(4-(Morpholinosulfonyl)phenyl)ethan-1-ol (CAS 1031659-70-7)
- (S)-3-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-2-one (CAS 1260605-92-2)
- Taurine-d4 (CAS 342611-14-7)
- Prilocaine impurity 40 HCl (CAS 780037-66-3（free base）)
- 2-(3-Piperidinylmethyl)-1,2,3,4-tetrahydroisoquinoline dihydrochloride (CAS 1220019-49-7)
- (2R)-2-amino-2-(3-bromo-4-hydroxyphenyl)acetic acid (CAS 139517-61-6)
- (Z)-3-Cyclopropylcarbamoyl-acrylic acid (CAS 925413-02-1)
- 1-Naphthyl 2-(6-Methoxy-2-naphthyl)propanoate (CAS 1385694-62-1)
- N-(4-Hydroxy-2-methoxyphenyl)methanesulfonamide (CAS 1243402-74-5)
- Tau Peptide (245-274) (Repeat 1 Domain) trifluoroacetate salt (CAS 1428134-39-7)
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