Estriol impurity 22 CAS 69227-81-2
| CAS No. | 69227-81-2 |
| Molecular Formula | C21H30O3 |
| Molecular Weight | 330.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, a hydroxyl group, an ether linkage, Estriol impurity 22 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 330.46 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Estriol impurity 22 (CAS 69227-81-2), a pharmacopoeial impurity reference standard (molecular formula C21H30O3, MW 330.46 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Estriol impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H30O3 |
| Molecular Weight | 330.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
Related Estriol Standards
- Estriol EP Impurity K (CAS 901-93-9)
- Estriol Impurity 20 (CAS CATO-C4X-163720)
- Estriol Impurity N1 (CAS 58001-91-5)
- Estriol EP Impurity C (CAS 1474-53-9)
- 6-Oxo Estriol (CAS 7323-86-6)
- Estriol Impurity 21 (CAS CATO-C4X-163721)
- Estriol Impurity 12 (CAS CATO-C4X-163712)
- Estriol Impurity 18 (CAS CATO-C4X-163718)
Recommended Standards
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- Trazodone impurity 76 (CAS CATO-C4X-177276)
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- Methyl (E)-2-(1-(3,4-dichlorophenyl)ethylidene)hydrazine-1-carboxylate (CAS 337924-73-9)
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Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com