Efinaconazole Impurity 36 CAS 6965-45-3
| CAS No. | 6965-45-3 |
| Molecular Formula | C12H6F4 |
| Molecular Weight | 226.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Efinaconazole Impurity 36 (C12H6F4) contains fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Efinaconazole Impurity 36 (CAS 6965-45-3) is a certified pharmaceutical impurity reference standard with the molecular formula C12H6F4 and a molecular weight of 226.17 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Efinaconazole Impurity 36 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H6F4 |
| Molecular Weight | 226.17 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
Related Efinaconazole Standards
- Efinaconazole Metabolite H3-13C2D (CAS CATO-C4X-124349)
- Efinaconazole Impurity 33 (CAS CATO-C4X-124333)
- Efinaconazole Impurity 28 (CAS 63608-15-1)
- Efinaconazole Impurity 56 (CAS 86386-74-5)
- Efinaconazole Impurity (CAS 909274-76-6)
- Efinaconazole Impurity 34 (CAS 135270-08-5)
- Efinaconazole (2S,3R) epoxide, 98% (CAS 132563-77-0)
- Efinaconazole Impurity 14 (CAS 135270-10-9)
Recommended Standards
- Isavuconazole Impurity 224 (CAS CATO-C4X-1236224)
- Ethyl 6,8-difluoroimidazo[1,2-a]pyridine-2-carboxylate (CAS 1000844-18-7)
- N-acetyl-D-[UL-¹³C6]glucosamine (CAS 478518-83-1)
- Triethyl phosphonoacetate-<SUP>13</SUP>C<SUB>2</SUB> (CAS 100940-60-1)
- Sitafloxacin impurity 11 (CAS 1799439-05-6)
- Aztreonam impurity 71 (CAS CATO-C4X-152271)
- Diquafosol Impurity 12 (CAS 19817-92-6)
- Phenyl(thieno[3,4-d][1,3]dioxol-4-yl)methanol (CAS 327070-52-0)
- Etoposide EP Impurity G (CAS CATO-C4X-20247)
- 2-Acetylhydrazinecarboxamide (CAS 2302-87-6)
- 4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-methyl-1H-pyrazole-3-carboxylic acid (CAS 2243514-25-0)
- 2-(4-Benzhydrylpiperazin-1-yl)-6-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine (CAS 337928-47-9)
- 1-(2-{[(Tert-butoxy)carbonyl]amino}ethyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 903094-73-5)
- Semaglutide impurity 99 (CAS CATO-C4X-222699)
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